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Abstract Multimode fibers (MMFs) are gaining renewed interest for nonlinear effects due to their high-dimensional spatiotemporal nonlinear dynamics and scalability for high power. High-brightness MMF sources with effective control of the nonlinear processes would offer possibilities in many areas from high-power fiber lasers, to bioimaging and chemical sensing, and to intriguing physics phenomena. Here we present a simple yet effective way of controlling nonlinear effects at high peak power levels. This is achieved by leveraging not only the spatial but also the temporal degrees of freedom during multimodal nonlinear pulse propagation in step-index MMFs, using a programmable fiber shaper that introduces time-dependent disorders. We achieve high tunability in MMF output fields, resulting in a broadband high-peak-power source. Its potential as a nonlinear imaging source is further demonstrated through widely tunable two-photon and three-photon microscopy. These demonstrations provide possibilities for technology advances in nonlinear optics, bioimaging, spectroscopy, optical computing, and material processing. 

High-precision light manipulation is crucial for delivering information through complex media. However, existing spatial light modulation devices face a fundamental speed-fidelity tradeoff. Digital micromirror devices have emerged as a promising candidate for high-speed wavefront shaping but at the cost of compromised fidelity due to the limited control degrees of freedom. Here, we leverage the sparse-to-random transformation through complex media to overcome the dimensionality limitation of spatial light modulation devices. We demonstrate that pattern compression by sparsity-constrained wavefront optimization allows sparse and robust wavefront representations in complex media, improving the projection fidelity without sacrificing frame rate, hardware complexity, or optimization time. Our method is generalizable to different pattern types and complex media, supporting consistent performance with up to 89% and 126% improvements in projection accuracy and speckle suppression, respectively. The proposed optimization framework could enable high-fidelity high-speed wavefront shaping through different scattering media and platforms without changes to the existing holographic setups, facilitating a wide range of physics and real-world applications. 

Label-free imaging through two-photon autofluorescence of NAD(P)H allows for nondestructive, high-resolution visualization of cellular activities in living systems. However, its application to thick tissues has been restricted by its limited penetration depth within 300 μm, largely due to light scattering. Here, we demonstrate that the imaging depth for NAD(P)H can be extended to more than 700 μm in living engineered human multicellular microtissues by adopting multimode fiber-based, low repetition rate, high peak power, three-photon excitation of NAD(P)H at 1100 nm. This is achieved by having more than 0.5 megawatts peak power at the band of 1100 ± 25 nm through adaptively modulating multimodal nonlinear pulse propagation with a compact fiber shaper. Moreover, the eightfold increase in pulse energy enables faster imaging of monocyte behaviors in the living multicellular models. These results represent a substantial advance for deep and dynamic imaging of intact living biosystems. The modular design is anticipated to allow wide adoption for demanding imaging applications, including cancer research, immune responses, and tissue engineering. 

Serendipity is a notion that means an unexpected but valuable discovery. Due to its elusive and subjective nature, serendipity is difficult to study even with today's advances in machine learning and deep learning techniques. Both ground truth data collecting and model developing are the open research questions. This paper addresses both the data and the model challenges for identifying serendipity in recommender systems. For the ground truth data collecting, it proposes a new and scalable approach by using both user generated reviews and a crowd sourcing method. The result is a large-scale ground truth data on serendipity. For model developing, it designed a self-enhanced module to learn the fine-grained facets of serendipity in order to mitigate the inherent data sparsity problem in any serendipity ground truth dataset. The self-enhanced module is general enough to be applied with many base deep learning models for serendipity. A series of experiments have been conducted. As the result, a base deep learning model trained on our collected ground truth data, as well as with the help of the self-enhanced module, outperforms the state-of-the-art baseline models in predicting serendipity. 

As the popularity of online travel platforms increases, users tend to make ad-hoc decisions on places to visit rather than preparing the detailed tour plans in advance. Under the situation of timeliness and uncertainty of users’ demand, how to integrate real-time context into a dynamic and personalized recommendations have become a key issue in travel recommender system. In this paper, by integrating the users’ historical preferences and real-time context, a location-aware recommender system called TRACE (Travel Reinforcement Recommendations Based on Location-Aware Context Extraction) is proposed. It captures users’ features based on location-aware context learning model, and makes dynamic recommendations based on reinforcement learning. Specifically, this research: (1) designs a travel reinforcing recommender system based on an Actor-Critic framework, which can dynamically track the user preference shifts and optimize the recommender system performance; (2) proposes a location-aware context learning model, which aims at extracting user context from real-time location and then calculating the impacts of nearby attractions on users’ preferences; and (3) conducts both offline and online experiments. Our proposed model achieves the best performance in both of the two experiments, which demonstrates that tracking the users’ preference shifts based on real-time location is valuable for improving the recommendation results.