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  1. In this study, we introduce a novel representation of patient data called Disease Severity Hierarchy (DSH) that explores specific diseases and their known treatment pathways in a nested fashion to create subpopulations in a clinically meaningful way. As the DSH tree is traversed from the root towards the leaves, we encounter subpopulations that share increasing richer amounts of clinical details such as similar disease severity, illness trajectories, and time to event that are discriminative, and suitable for learning risk stratification models. The proposed DSH risk scores effectively and accurately predict the age at which a patient may be at risk of dying or developing MCE significantly better than a traditional representation of disease conditions. DSH utilizes known relationships among various entities in EHR data to capture disease severity in a natural way and has the additional benefit of being expressive and interpretable. This novel patient representation can help support critical decision making, development of smart EBP guidelines, and enhance healthcare care and disease management by helping to identify and reduce disease burden among high-risk patients.
  2. Different analytic techniques operate optimally with different types of data. As the use of EHR-based analytics expands to newer tasks, data will have to be transformed into different representations, so the tasks can be optimally solved. We classified representations into broad categories based on their characteristics and proposed a new knowledge-driven representation for clinical data mining as well as trajectory mining, called Severity Encoding Variables (SEVs). Additionally, we studied which characteristics make representations most suitable for particular clinical analytics tasks including trajectory mining. Our evaluation shows that, for regression, most data representations performed similarly, with SEV achieving a slight (albeit statistically significant) advantage. For patients at high risk of diabetes, it outperformed the competing representation by (relative) 20%. For association mining, SEV achieved the highest performance. Its ability to constrain the search space of patterns through clinical knowledge was key to its success.