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Controlled Single-Cell Compression With a High-Throughput MEMS Actuator

https://doi.org/10.1109/JMEMS.2020.3005514

Walker, Jennifer L.; Patterson, Luke H.; Rodriguez-Mesa, Evelyn; Shields, Kevin; Foster, John S.; Valentine, Megan T.; Doyle, Adele M.; Foster, Kimberly L. (October 2020, Journal of Microelectromechanical Systems)
null (Ed.)
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Inertial flow focusing: a case study in optimizing cellular trajectory through a microfluidic MEMS device for timing-critical applications

https://doi.org/10.1007/s10544-020-00508-1

Patterson, Luke H.C.; Walker, Jennifer L.; Naivar, Mark A.; Rodriguez-Mesa, Evelyn; Hoonejani, Mehran R.; Shields, Kevin; Foster, John S.; Doyle, Adele M.; Valentine, Megan T.; Foster, Kimberly L. (September 2020, Biomedical Microdevices)
null (Ed.)
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Investigating Cellular Response to Impact With a Microfluidic MEMS Device

https://doi.org/10.1109/JMEMS.2019.2948895

Patterson, Luke H. C.; Walker, Jennifer L.; Rodriguez-Mesa, Evelyn; Shields, Kevin; Foster, John S.; Valentine, Megan T.; Doyle, Adele M.; Foster, Kimberly L. (February 2020, Journal of Microelectromechanical Systems)
THE μHAMMER: INVESTIGATING CELLULAR RESPONSE TO IMPACT WITH A HIGH THROUGHPUT MICROFLUIDIC MEMS DEVICE

https://doi.org/10.31438/trf.hh2018.47

Patterson, L.H.C.; Walker, J.L.; Rodriguez-Mesa, E.; Shields, K.; Foster, J.S.; Valentine, M.T.; Doyle, A.M.; Foster, K.L. (January 2018, Solid-State Sensor, Actuator, and Microsystems Workshop, Hilton Head, SC)

We report the application of stress to biological cells at unprecedented strain (50%), strain rate (180,000 s-1), and throughput (1,800 cells/min) using a high-speed, high actuation force magnetically-driven MEMS chip. This device is uniquely suited to study the effects of impact on large populations of inherently heterogeneous cells, enabling statistical analysis that can elucidate the cell-level ramifications of Traumatic Brain Injury (TBI). To demonstrate the capabilities of the μHammer, we applied TBI-relevant strains and strain rates to human leukemic K562 cells then monitored their proliferation for 9 days. We observed significantly repressed proliferation of the hit cells compared to both the negative and sham controls, indicating success in applying sublethal cellular damage.
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