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Regiodivergent biocatalytic hydroxylation of l-Glutamine facilitated by characterization of Non-Heme dioxygenases from Non-Ribosomal peptide biosyntheses

https://doi.org/10.1016/j.tet.2021.132190

Renata, Hans; Shimizu, Emily; Zwick, Christian R. (June 2021, Tetrahedron)

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Modular Chemoenzymatic Synthesis of GE81112 B1 and Related Analogues Enables Elucidation of Its Key Pharmacophores

https://doi.org/10.1021/jacs.0c13424

Zwick, Christian R.; Sosa, Max B.; Renata, Hans (January 2021, Journal of the American Chemical Society)

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A molecular switch regulating transcriptional repression and activation of PPARγ

https://doi.org/10.1038/s41467-020-14750-x

Shang, Jinsai; Mosure, Sarah A.; Zheng, Jie; Brust, Richard; Bass, Jared; Nichols, Ashley; Solt, Laura A.; Griffin, Patrick R.; Kojetin, Douglas J. (December 2020, Nature Communications)

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Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule–Deglycobleomycin Conjugate

https://doi.org/10.1021/acschembio.0c00036

Angelbello, Alicia J.; DeFeo, Mary E.; Glinkerman, Christopher M.; Boger, Dale L.; Disney, Matthew D. (January 2020, ACS Chemical Biology)

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Characterization of a Citrulline 4‐Hydroxylase from Nonribosomal Peptide GE81112 Biosynthesis and Engineering of Its Substrate Specificity for the Chemoenzymatic Synthesis of Enduracididine

https://doi.org/10.1002/anie.201910659

Zwick, Christian R.; Sosa, Max B.; Renata, Hans (December 2019, Angewandte Chemie International Edition)

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A complex containing the O -GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function

https://doi.org/10.1074/jbc.RA119.007406

Giles, Andrew C.; Desbois, Muriel; Opperman, Karla J.; Tavora, Rubens; Maroni, Marissa J.; Grill, Brock (April 2019, Journal of Biological Chemistry)

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