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Abstract Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (Io) were designed for binding A–U base pairs in double‐stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A–U using theIoscaffold in PNA. PNAs having four sequentialIoextended nucleobases maintained high binding affinity.more » « less
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Kumpina, Ilze; Brodyagin, Nikita; MacKay, James A.; Kennedy, Scott D.; Katkevics, Martins; Rozners, Eriks (, The Journal of Organic Chemistry)
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Kotikam, Venubabu; Kennedy, Scott D.; MacKay, James A.; Rozners, Eriks (, Chemistry – A European Journal)
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