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Abstract Many traits are subject to assortative mating, with recent molecular genetic findings confirming longstanding theoretical predictions that assortative mating induces long range dependence across causal variants. However, all marker-based heritability estimators implicitly assume mating is random. We provide mathematical and simulation-based evidence demonstrating that both method-of-moments and likelihood-based estimators are biased in the presence of assortative mating and derive corrected heritability estimators for traits subject to assortment. Finally, we demonstrate that the empirical patterns of estimates across methods and sample sizes for real traits subject to assortative mating are congruent with expected assortative mating-induced biases. For example, marker-based heritability estimates for height are 14% – 23% higher than corrected estimates using UK Biobank data.more » « less
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Improving upon results of Rudelson and Vershynin, we establish delocalization bounds for eigenvectors of independent‐entry random matrices. In particular, we show that with high probability every eigenvector is delocalized, meaning any subset of its coordinates carries an appropriate proportion of its mass. Our results hold for random matrices with genuinely complex as well as real entries. As an application of our methods, we also establish delocalization bounds for normal vectors to random hyperplanes. The proofs of our main results rely on a least singular value bound for genuinely complex rectangular random matrices, which generalizes a previous bound due to the first author, and may be of independent interest.more » « less
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