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  1. Obeid, Iyad Selesnick (Ed.)
    Scalp electroencephalogram (EEG) signals inherently have a low signal-to-noise ratio due to the way the signal is electrically transduced. Temporal and spatial information must be exploited to achieve accurate detection of seizure events. Most popular approaches to seizure detection using deep learning do not jointly model this information or require multiple passes over the signal, which makes the systems inherently non-causal. In this paper, we exploit both simultaneously by converting the multichannel signal to a grayscale image and using transfer learning to achieve high performance. The proposed system is trained end-to-end with only very simple pre- and post-processing operations which are computationally lightweight and have low latency, making them conducive to clinical applications that require real-time processing. We have achieved a performance of 42.05% sensitivity with 5.78 false alarm per 24 hours on the development dataset of v1.5.2 of the Temple University Hospital Seizure Detection Corpus. On a single core CPU operating at 1.7 GHz, the system runs faster than real-time (0.58 xRT), uses 16 Gbytes of memory, and has a latency of 300 msec. 
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  2. Obeid, Iyad Selesnick (Ed.)
    The Temple University Hospital EEG Corpus (TUEG) [1] is the largest publicly available EEG corpus of its type and currently has over 5,000 subscribers (we currently average 35 new subscribers a week). Several valuable subsets of this corpus have been developed including the Temple University Hospital EEG Seizure Corpus (TUSZ) [2] and the Temple University Hospital EEG Artifact Corpus (TUAR) [3]. TUSZ contains manually annotated seizure events and has been widely used to develop seizure detection and prediction technology [4]. TUAR contains manually annotated artifacts and has been used to improve machine learning performance on seizure detection tasks [5]. In this poster, we will discuss recent improvements made to both corpora that are creating opportunities to improve machine learning performance. Two major concerns that were raised when v1.5.2 of TUSZ was released for the Neureka 2020 Epilepsy Challenge were: (1) the subjects contained in the training, development (validation) and blind evaluation sets were not mutually exclusive, and (2) high frequency seizures were not accurately annotated in all files. Regarding (1), there were 50 subjects in dev, 50 subjects in eval, and 592 subjects in train. There was one subject common to dev and eval, five subjects common to dev and train, and 13 subjects common between eval and train. Though this does not substantially influence performance for the current generation of technology, it could be a problem down the line as technology improves. Therefore, we have rebuilt the partitions of the data so that this overlap was removed. This required augmenting the evaluation and development data sets with new subjects that had not been previously annotated so that the size of these subsets remained approximately the same. Since these annotations were done by a new group of annotators, special care was taken to make sure the new annotators followed the same practices as the previous generations of annotators. Part of our quality control process was to have the new annotators review all previous annotations. This rigorous training coupled with a strict quality control process where annotators review a significant amount of each other’s work ensured that there is high interrater agreement between the two groups (kappa statistic greater than 0.8) [6]. In the process of reviewing this data, we also decided to split long files into a series of smaller segments to facilitate processing of the data. Some subscribers found it difficult to process long files using Python code, which tends to be very memory intensive. We also found it inefficient to manipulate these long files in our annotation tool. In this release, the maximum duration of any single file is limited to 60 mins. This increased the number of edf files in the dev set from 1012 to 1832. Regarding (2), as part of discussions of several issues raised by a few subscribers, we discovered some files only had low frequency epileptiform events annotated (defined as events that ranged in frequency from 2.5 Hz to 3 Hz), while others had events annotated that contained significant frequency content above 3 Hz. Though there were not many files that had this type of activity, it was enough of a concern to necessitate reviewing the entire corpus. An example of an epileptiform seizure event with frequency content higher than 3 Hz is shown in Figure 1. Annotating these additional events slightly increased the number of seizure events. In v1.5.2, there were 673 seizures, while in v1.5.3 there are 1239 events. One of the fertile areas for technology improvements is artifact reduction. Artifacts and slowing constitute the two major error modalities in seizure detection [3]. This was a major reason we developed TUAR. It can be used to evaluate artifact detection and suppression technology as well as multimodal background models that explicitly model artifacts. An issue with TUAR was the practicality of the annotation tags used when there are multiple simultaneous events. An example of such an event is shown in Figure 2. In this section of the file, there is an overlap of eye movement, electrode artifact, and muscle artifact events. We previously annotated such events using a convention that included annotating background along with any artifact that is present. The artifacts present would either be annotated with a single tag (e.g., MUSC) or a coupled artifact tag (e.g., MUSC+ELEC). When multiple channels have background, the tags become crowded and difficult to identify. This is one reason we now support a hierarchical annotation format using XML – annotations can be arbitrarily complex and support overlaps in time. Our annotators also reviewed specific eye movement artifacts (e.g., eye flutter, eyeblinks). Eye movements are often mistaken as seizures due to their similar morphology [7][8]. We have improved our understanding of ocular events and it has allowed us to annotate artifacts in the corpus more carefully. In this poster, we will present statistics on the newest releases of these corpora and discuss the impact these improvements have had on machine learning research. We will compare TUSZ v1.5.3 and TUAR v2.0.0 with previous versions of these corpora. We will release v1.5.3 of TUSZ and v2.0.0 of TUAR in Fall 2021 prior to the symposium. ACKNOWLEDGMENTS Research reported in this publication was most recently supported by the National Science Foundation’s Industrial Innovation and Partnerships (IIP) Research Experience for Undergraduates award number 1827565. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the official views of any of these organizations. REFERENCES [1] I. Obeid and J. Picone, “The Temple University Hospital EEG Data Corpus,” in Augmentation of Brain Function: Facts, Fiction and Controversy. Volume I: Brain-Machine Interfaces, 1st ed., vol. 10, M. A. Lebedev, Ed. Lausanne, Switzerland: Frontiers Media S.A., 2016, pp. 394 398. https://doi.org/10.3389/fnins.2016.00196. [2] V. Shah et al., “The Temple University Hospital Seizure Detection Corpus,” Frontiers in Neuroinformatics, vol. 12, pp. 1–6, 2018. https://doi.org/10.3389/fninf.2018.00083. [3] A. Hamid et, al., “The Temple University Artifact Corpus: An Annotated Corpus of EEG Artifacts.” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2020, pp. 1-3. https://ieeexplore.ieee.org/document/9353647. [4] Y. Roy, R. Iskander, and J. Picone, “The NeurekaTM 2020 Epilepsy Challenge,” NeuroTechX, 2020. [Online]. Available: https://neureka-challenge.com/. [Accessed: 01-Dec-2021]. [5] S. Rahman, A. Hamid, D. Ochal, I. Obeid, and J. Picone, “Improving the Quality of the TUSZ Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2020, pp. 1–5. https://ieeexplore.ieee.org/document/9353635. [6] V. Shah, E. von Weltin, T. Ahsan, I. Obeid, and J. Picone, “On the Use of Non-Experts for Generation of High-Quality Annotations of Seizure Events,” Available: https://www.isip.picone press.com/publications/unpublished/journals/2019/elsevier_cn/ira. [Accessed: 01-Dec-2021]. [7] D. Ochal, S. Rahman, S. Ferrell, T. Elseify, I. Obeid, and J. Picone, “The Temple University Hospital EEG Corpus: Annotation Guidelines,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/tuh_eeg/annotations/. [8] D. Strayhorn, “The Atlas of Adult Electroencephalography,” EEG Atlas Online, 2014. [Online]. Availabl 
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  3. null (Ed.)
  4. Obeid, Iyad ; Selesnick, Ivan ; Picone, Joseph (Ed.)
    The evaluation of machine learning algorithms in biomedical fields for ap-plications involving sequential data lacks both rigor and standardization. Common quantitative scalar evaluation metrics such as sensitivity and specificity can often be misleading and not accurately integrate application requirements. Evaluation metrics must ultimately reflect the needs of users yet be sufficiently sensitive to guide algorithm development. For example, feedback from critical care clinicians who use automated event detection software in clinical applications has been overwhelmingly emphatic that a low false alarm rate, typically measured in units of the number of errors per 24 hours, is the single most important criterion for user acceptance. Though using a single metric is not often as insightful as examining performance over a range of operating conditions, there is, nevertheless, a need for a sin-gle scalar figure of merit. In this chapter, we discuss the deficiencies of existing metrics for a seizure detection task and propose several new metrics that offer a more balanced view of performance. We demonstrate these metrics on a seizure detection task based on the TUH EEG Seizure Corpus. We introduce two promising metrics: (1) a measure based on a concept borrowed from the spoken term detection literature, Actual Term-Weighted Value, and (2) a new metric, Time-Aligned Event Scoring (TAES), that accounts for the temporal align-ment of the hypothesis to the reference annotation. We demonstrate that state of the art technology based on deep learning, though impressive in its performance, still needs significant improvement before it will meet very strict user acceptance guidelines. 
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  5. Obeid, Iyad ; Selesnick, Ivan ; Picone, Joseph (Ed.)
    The Temple University Hospital Seizure Detection Corpus (TUSZ) [1] has been in distribution since April 2017. It is a subset of the TUH EEG Corpus (TUEG) [2] and the most frequently requested corpus from our 3,000+ subscribers. It was recently featured as the challenge task in the Neureka 2020 Epilepsy Challenge [3]. A summary of the development of the corpus is shown below in Table 1. The TUSZ Corpus is a fully annotated corpus, which means every seizure event that occurs within its files has been annotated. The data is selected from TUEG using a screening process that identifies files most likely to contain seizures [1]. Approximately 7% of the TUEG data contains a seizure event, so it is important we triage TUEG for high yield data. One hour of EEG data requires approximately one hour of human labor to complete annotation using the pipeline described below, so it is important from a financial standpoint that we accurately triage data. A summary of the labels being used to annotate the data is shown in Table 2. Certain standards are put into place to optimize the annotation process while not sacrificing consistency. Due to the nature of EEG recordings, some records start off with a segment of calibration. This portion of the EEG is instantly recognizable and transitions from what resembles lead artifact to a flat line on all the channels. For the sake of seizure annotation, the calibration is ignored, and no time is wasted on it. During the identification of seizure events, a hard “3 second rule” is used to determine whether two events should be combined into a single larger event. This greatly reduces the time that it takes to annotate a file with multiple events occurring in succession. In addition to the required minimum 3 second gap between seizures, part of our standard dictates that no seizure less than 3 seconds be annotated. Although there is no universally accepted definition for how long a seizure must be, we find that it is difficult to discern with confidence between burst suppression or other morphologically similar impressions when the event is only a couple seconds long. This is due to several reasons, the most notable being the lack of evolution which is oftentimes crucial for the determination of a seizure. After the EEG files have been triaged, a team of annotators at NEDC is provided with the files to begin data annotation. An example of an annotation is shown in Figure 1. A summary of the workflow for our annotation process is shown in Figure 2. Several passes are performed over the data to ensure the annotations are accurate. Each file undergoes three passes to ensure that no seizures were missed or misidentified. The first pass of TUSZ involves identifying which files contain seizures and annotating them using our annotation tool. The time it takes to fully annotate a file can vary drastically depending on the specific characteristics of each file; however, on average a file containing multiple seizures takes 7 minutes to fully annotate. This includes the time that it takes to read the patient report as well as traverse through the entire file. Once an event has been identified, the start and stop time for the seizure is stored in our annotation tool. This is done on a channel by channel basis resulting in an accurate representation of the seizure spreading across different parts of the brain. Files that do not contain any seizures take approximately 3 minutes to complete. Even though there is no annotation being made, the file is still carefully examined to make sure that nothing was overlooked. In addition to solely scrolling through a file from start to finish, a file is often examined through different lenses. Depending on the situation, low pass filters are used, as well as increasing the amplitude of certain channels. These techniques are never used in isolation and are meant to further increase our confidence that nothing was missed. Once each file in a given set has been looked at once, the annotators start the review process. The reviewer checks a file and comments any changes that they recommend. This takes about 3 minutes per seizure containing file, which is significantly less time than the first pass. After each file has been commented on, the third pass commences. This step takes about 5 minutes per seizure file and requires the reviewer to accept or reject the changes that the second reviewer suggested. Since tangible changes are made to the annotation using the annotation tool, this step takes a bit longer than the previous one. Assuming 18% of the files contain seizures, a set of 1,000 files takes roughly 127 work hours to annotate. Before an annotator contributes to the data interpretation pipeline, they are trained for several weeks on previous datasets. A new annotator is able to be trained using data that resembles what they would see under normal circumstances. An additional benefit of using released data to train is that it serves as a means of constantly checking our work. If a trainee stumbles across an event that was not previously annotated, it is promptly added, and the data release is updated. It takes about three months to train an annotator to a point where their annotations can be trusted. Even though we carefully screen potential annotators during the hiring process, only about 25% of the annotators we hire survive more than one year doing this work. To ensure that the annotators are consistent in their annotations, the team conducts an interrater agreement evaluation periodically to ensure that there is a consensus within the team. The annotation standards are discussed in Ochal et al. [4]. An extended discussion of interrater agreement can be found in Shah et al. [5]. The most recent release of TUSZ, v1.5.2, represents our efforts to review the quality of the annotations for two upcoming challenges we hosted: an internal deep learning challenge at IBM [6] and the Neureka 2020 Epilepsy Challenge [3]. One of the biggest changes that was made to the annotations was the imposition of a stricter standard for determining the start and stop time of a seizure. Although evolution is still included in the annotations, the start times were altered to start when the spike-wave pattern becomes distinct as opposed to merely when the signal starts to shift from background. This cuts down on background that was mislabeled as a seizure. For seizure end times, all post ictal slowing that was included was removed. The recent release of v1.5.2 did not include any additional data files. Two EEG files had been added because, originally, they were corrupted in v1.5.1 but were able to be retrieved and added for the latest release. The progression from v1.5.0 to v1.5.1 and later to v1.5.2, included the re-annotation of all of the EEG files in order to develop a confident dataset regarding seizure identification. Starting with v1.4.0, we have also developed a blind evaluation set that is withheld for use in competitions. The annotation team is currently working on the next release for TUSZ, v1.6.0, which is expected to occur in August 2020. It will include new data from 2016 to mid-2019. This release will contain 2,296 files from 2016 as well as several thousand files representing the remaining data through mid-2019. In addition to files that were obtained with our standard triaging process, a part of this release consists of EEG files that do not have associated patient reports. Since actual seizure events are in short supply, we are mining a large chunk of data for which we have EEG recordings but no reports. Some of this data contains interesting seizure events collected during long-term EEG sessions or data collected from patients with a history of frequent seizures. It is being mined to increase the number of files in the corpus that have at least one seizure event. We expect v1.6.0 to be released before IEEE SPMB 2020. The TUAR Corpus is an open-source database that is currently available for use by any registered member of our consortium. To register and receive access, please follow the instructions provided at this web page: https://www.isip.piconepress.com/projects/tuh_eeg/html/downloads.shtml. The data is located here: https://www.isip.piconepress.com/projects/tuh_eeg/downloads/tuh_eeg_artifact/v2.0.0/. 
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  6. Obeid, Iyad ; Selesnick, Ivan ; Picone, Joseph (Ed.)
    There has been a lack of standardization of the evaluation of sequential decoding systems in the bioengineering community. Assessment of the accuracy of a candidate system’s segmentations and measurement of a false alarm rate are examples of two performance metrics that are very critical to the operational acceptance of a technology. However, measurement of such quantities in a consistent manner require many scoring software implementation details to be resolved. Results can be highly sensitive to these implementation details. In this paper, we revisit and evaluate a set of metrics introduced in our open source scoring software for sequential decoding of multichannel signals. This software was used to rank sixteen automatic seizure detection systems recently developed for the 2020 Neureka® Epilepsy Challenge. The systems produced by the participants provided us with a broad range of design variations that allowed assessment of the consistency of the proposed metrics. We present a comprehensive assessment of four of these new metrics and validate our findings with our previous studies. We also validate a proposed new metric, time-aligned event scoring, that focuses on the segmentation behavior of an algorithm. We demonstrate how we can gain insight into the performance of a system using these metrics. 
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  7. Obeid, Iyad ; Selesnick, Ivan ; Picone, Joseph (Ed.)
    The Neural Engineering Data Consortium has recently developed a new subset of its popular open source EEG corpus – TUH EEG (TUEG) [1]. The TUEG Corpus is the world’s largest open source corpus of EEG data and currently has over 3,300 subscribers. There are several valuable subsets of this data, including the TUH Seizure Detection Corpus (TUSZ) [2], which was featured in the Neureka 2020 Epilepsy Challenge [3]. In this poster, we present a new subset of the TUEG Corpus – the TU Artifact Corpus. This corpus contains 310 EEG files in which every artifact has been annotated. This data can be used to evaluate artifact reduction technology. Since TUEG is comprised of actual clinical data, the set of artifacts appearing in the data is rich and challenging. EEG artifacts are defined as waveforms that are not of cerebral origin and may be affected by numerous external and or physiological factors. These extraneous signals are often mistaken for seizures due to their morphological similarity in amplitude and frequency [4]. Artifacts often lead to raised false alarm rates in machine learning systems, which poses a major challenge for machine learning research. Most state-of-the-art systems use some form of artifact reduction technology to suppress these events. The corpus was annotated using a five-way classification that was developed to meet the needs of our constituents. Brief descriptions of each form of the artifact are provided in Ochal et al. [4]. The five basic tags are: • Chewing (CHEW): An artifact resulting from the tensing and relaxing of the jaw muscles. Chewing is a subset of the muscle artifact class. Chewing has the same characteristic high frequency sharp waves with 0.5 sec baseline periods between bursts. This artifact is generally diffuse throughout the different regions of the brain. However, it might have a higher level of activity in one hemisphere. Classification of a muscle artifact as chewing often depends on whether the accompanying patient report mentions any chewing, since other muscle artifacts can appear superficially similar to chewing artifact. • Electrode (ELEC): An electrode artifact encompasses various electrode related artifacts. Electrode pop is an artifact characterized by channels using the same electrode “spiking” with an electrographic phase reversal. Electrostatic is an artifact caused by movement or interference of electrodes and or the presence of dissimilar metals. A lead artifact is caused by the movement of electrodes from the patient’s head and or poor connection of electrodes. This results in disorganized and high amplitude slow waves. • Eye Movement (EYEM): A spike-like waveform created during patient eye movement. This artifact is usually found on all of the frontal polar electrodes with occasional echoing on the frontal electrodes. • Muscle (MUSC): A common artifact with high frequency, sharp waves corresponding to patient movement. These waveforms tend to have a frequency above 30 Hz with no specific pattern, often occurring because of agitation in the patient. • Shiver (SHIV): A specific and sustained sharp wave artifact that occurs when a patient shivers, usually seen on all or most channels. Shivering is a relatively rare subset of the muscle artifact class. Since these artifacts can overlap in time, a concatenated label format was implemented as a compromise between the limitations of our annotation tool and the complexity needed in an annotation data structure used to represent these overlapping events. We distribute an XML format that easily handles overlapping events. Our annotation tool [5], like most annotation tools of this type, is limited to displaying and manipulating a flat or linear annotation. Therefore, we encode overlapping events as a series of concatenated names using symbols such as: • EYEM+CHEW: eye movement and chewing • EYEM+SHIV: eye movement and shivering • CHEW+SHIV: chewing and shivering An example of an overlapping annotation is shown below in Figure 1. This release is an update of TUAR v1.0.0, which was a partially annotated database. In v1.0.0, a similar five way system was used as well as an additional “null” tag. The “null” tag covers anything that was not annotated, including instances of artifact. Only a limited number of artifacts were annotated in v1.0.0. In this updated version, every instance of an artifact is annotated; ultimately, this provides the user with confidence that any part of the record that is not annotated with one of the five classes does not contain an artifact. No new files, patients, or sessions were added in v2.0.0. However, the data was reannotated with these standards. The total number of files remains the same, but the number of artifact events increases significantly. Complete statistics will be provided on the corpus once annotation is complete and the data is released. This is expected to occur in early July – just after the IEEE SPMB submission deadline. The TUAR Corpus is an open-source database that is currently available for use by any registered member of our consortium. To register and receive access, please follow the instructions provided at this web page: https://www.isip.piconepress.com/projects/tuh_eeg/html/downloads.shtml. The data is located here: https://www.isip.piconepress.com/projects/tuh_eeg/downloads/tuh_eeg_artifact/v2.0.0/. 
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  8. Obeid, Iyad Selesnick (Ed.)
    Electroencephalography (EEG) is a popular clinical monitoring tool used for diagnosing brain-related disorders such as epilepsy [1]. As monitoring EEGs in a critical-care setting is an expensive and tedious task, there is a great interest in developing real-time EEG monitoring tools to improve patient care quality and efficiency [2]. However, clinicians require automatic seizure detection tools that provide decisions with at least 75% sensitivity and less than 1 false alarm (FA) per 24 hours [3]. Some commercial tools recently claim to reach such performance levels, including the Olympic Brainz Monitor [4] and Persyst 14 [5]. In this abstract, we describe our efforts to transform a high-performance offline seizure detection system [3] into a low latency real-time or online seizure detection system. An overview of the system is shown in Figure 1. The main difference between an online versus offline system is that an online system should always be causal and has minimum latency which is often defined by domain experts. The offline system, shown in Figure 2, uses two phases of deep learning models with postprocessing [3]. The channel-based long short term memory (LSTM) model (Phase 1 or P1) processes linear frequency cepstral coefficients (LFCC) [6] features from each EEG channel separately. We use the hypotheses generated by the P1 model and create additional features that carry information about the detected events and their confidence. The P2 model uses these additional features and the LFCC features to learn the temporal and spatial aspects of the EEG signals using a hybrid convolutional neural network (CNN) and LSTM model. Finally, Phase 3 aggregates the results from both P1 and P2 before applying a final postprocessing step. The online system implements Phase 1 by taking advantage of the Linux piping mechanism, multithreading techniques, and multi-core processors. To convert Phase 1 into an online system, we divide the system into five major modules: signal preprocessor, feature extractor, event decoder, postprocessor, and visualizer. The system reads 0.1-second frames from each EEG channel and sends them to the feature extractor and the visualizer. The feature extractor generates LFCC features in real time from the streaming EEG signal. Next, the system computes seizure and background probabilities using a channel-based LSTM model and applies a postprocessor to aggregate the detected events across channels. The system then displays the EEG signal and the decisions simultaneously using a visualization module. The online system uses C++, Python, TensorFlow, and PyQtGraph in its implementation. The online system accepts streamed EEG data sampled at 250 Hz as input. The system begins processing the EEG signal by applying a TCP montage [8]. Depending on the type of the montage, the EEG signal can have either 22 or 20 channels. To enable the online operation, we send 0.1-second (25 samples) length frames from each channel of the streamed EEG signal to the feature extractor and the visualizer. Feature extraction is performed sequentially on each channel. The signal preprocessor writes the sample frames into two streams to facilitate these modules. In the first stream, the feature extractor receives the signals using stdin. In parallel, as a second stream, the visualizer shares a user-defined file with the signal preprocessor. This user-defined file holds raw signal information as a buffer for the visualizer. The signal preprocessor writes into the file while the visualizer reads from it. Reading and writing into the same file poses a challenge. The visualizer can start reading while the signal preprocessor is writing into it. To resolve this issue, we utilize a file locking mechanism in the signal preprocessor and visualizer. Each of the processes temporarily locks the file, performs its operation, releases the lock, and tries to obtain the lock after a waiting period. The file locking mechanism ensures that only one process can access the file by prohibiting other processes from reading or writing while one process is modifying the file [9]. The feature extractor uses circular buffers to save 0.3 seconds or 75 samples from each channel for extracting 0.2-second or 50-sample long center-aligned windows. The module generates 8 absolute LFCC features where the zeroth cepstral coefficient is replaced by a temporal domain energy term. For extracting the rest of the features, three pipelines are used. The differential energy feature is calculated in a 0.9-second absolute feature window with a frame size of 0.1 seconds. The difference between the maximum and minimum temporal energy terms is calculated in this range. Then, the first derivative or the delta features are calculated using another 0.9-second window. Finally, the second derivative or delta-delta features are calculated using a 0.3-second window [6]. The differential energy for the delta-delta features is not included. In total, we extract 26 features from the raw sample windows which add 1.1 seconds of delay to the system. We used the Temple University Hospital Seizure Database (TUSZ) v1.2.1 for developing the online system [10]. The statistics for this dataset are shown in Table 1. A channel-based LSTM model was trained using the features derived from the train set using the online feature extractor module. A window-based normalization technique was applied to those features. In the offline model, we scale features by normalizing using the maximum absolute value of a channel [11] before applying a sliding window approach. Since the online system has access to a limited amount of data, we normalize based on the observed window. The model uses the feature vectors with a frame size of 1 second and a window size of 7 seconds. We evaluated the model using the offline P1 postprocessor to determine the efficacy of the delayed features and the window-based normalization technique. As shown by the results of experiments 1 and 4 in Table 2, these changes give us a comparable performance to the offline model. The online event decoder module utilizes this trained model for computing probabilities for the seizure and background classes. These posteriors are then postprocessed to remove spurious detections. The online postprocessor receives and saves 8 seconds of class posteriors in a buffer for further processing. It applies multiple heuristic filters (e.g., probability threshold) to make an overall decision by combining events across the channels. These filters evaluate the average confidence, the duration of a seizure, and the channels where the seizures were observed. The postprocessor delivers the label and confidence to the visualizer. The visualizer starts to display the signal as soon as it gets access to the signal file, as shown in Figure 1 using the “Signal File” and “Visualizer” blocks. Once the visualizer receives the label and confidence for the latest epoch from the postprocessor, it overlays the decision and color codes that epoch. The visualizer uses red for seizure with the label SEIZ and green for the background class with the label BCKG. Once the streaming finishes, the system saves three files: a signal file in which the sample frames are saved in the order they were streamed, a time segmented event (TSE) file with the overall decisions and confidences, and a hypotheses (HYP) file that saves the label and confidence for each epoch. The user can plot the signal and decisions using the signal and HYP files with only the visualizer by enabling appropriate options. For comparing the performance of different stages of development, we used the test set of TUSZ v1.2.1 database. It contains 1015 EEG records of varying duration. The any-overlap performance [12] of the overall system shown in Figure 2 is 40.29% sensitivity with 5.77 FAs per 24 hours. For comparison, the previous state-of-the-art model developed on this database performed at 30.71% sensitivity with 6.77 FAs per 24 hours [3]. The individual performances of the deep learning phases are as follows: Phase 1’s (P1) performance is 39.46% sensitivity and 11.62 FAs per 24 hours, and Phase 2 detects seizures with 41.16% sensitivity and 11.69 FAs per 24 hours. We trained an LSTM model with the delayed features and the window-based normalization technique for developing the online system. Using the offline decoder and postprocessor, the model performed at 36.23% sensitivity with 9.52 FAs per 24 hours. The trained model was then evaluated with the online modules. The current performance of the overall online system is 45.80% sensitivity with 28.14 FAs per 24 hours. Table 2 summarizes the performances of these systems. The performance of the online system deviates from the offline P1 model because the online postprocessor fails to combine the events as the seizure probability fluctuates during an event. The modules in the online system add a total of 11.1 seconds of delay for processing each second of the data, as shown in Figure 3. In practice, we also count the time for loading the model and starting the visualizer block. When we consider these facts, the system consumes 15 seconds to display the first hypothesis. The system detects seizure onsets with an average latency of 15 seconds. Implementing an automatic seizure detection model in real time is not trivial. We used a variety of techniques such as the file locking mechanism, multithreading, circular buffers, real-time event decoding, and signal-decision plotting to realize the system. A video demonstrating the system is available at: https://www.isip.piconepress.com/projects/nsf_pfi_tt/resources/videos/realtime_eeg_analysis/v2.5.1/video_2.5.1.mp4. The final conference submission will include a more detailed analysis of the online performance of each module. ACKNOWLEDGMENTS Research reported in this publication was most recently supported by the National Science Foundation Partnership for Innovation award number IIP-1827565 and the Pennsylvania Commonwealth Universal Research Enhancement Program (PA CURE). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the official views of any of these organizations. REFERENCES [1] A. Craik, Y. He, and J. L. Contreras-Vidal, “Deep learning for electroencephalogram (EEG) classification tasks: a review,” J. Neural Eng., vol. 16, no. 3, p. 031001, 2019. https://doi.org/10.1088/1741-2552/ab0ab5. [2] A. C. Bridi, T. Q. Louro, and R. C. L. Da Silva, “Clinical Alarms in intensive care: implications of alarm fatigue for the safety of patients,” Rev. Lat. Am. Enfermagem, vol. 22, no. 6, p. 1034, 2014. https://doi.org/10.1590/0104-1169.3488.2513. [3] M. Golmohammadi, V. Shah, I. Obeid, and J. Picone, “Deep Learning Approaches for Automatic Seizure Detection from Scalp Electroencephalograms,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York, New York, USA: Springer, 2020, pp. 233–274. https://doi.org/10.1007/978-3-030-36844-9_8. [4] “CFM Olympic Brainz Monitor.” [Online]. Available: https://newborncare.natus.com/products-services/newborn-care-products/newborn-brain-injury/cfm-olympic-brainz-monitor. [Accessed: 17-Jul-2020]. [5] M. L. Scheuer, S. B. Wilson, A. Antony, G. Ghearing, A. Urban, and A. I. Bagic, “Seizure Detection: Interreader Agreement and Detection Algorithm Assessments Using a Large Dataset,” J. Clin. Neurophysiol., 2020. https://doi.org/10.1097/WNP.0000000000000709. [6] A. Harati, M. Golmohammadi, S. Lopez, I. Obeid, and J. Picone, “Improved EEG Event Classification Using Differential Energy,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium, 2015, pp. 1–4. https://doi.org/10.1109/SPMB.2015.7405421. [7] V. Shah, C. Campbell, I. Obeid, and J. Picone, “Improved Spatio-Temporal Modeling in Automated Seizure Detection using Channel-Dependent Posteriors,” Neurocomputing, 2021. [8] W. Tatum, A. Husain, S. Benbadis, and P. Kaplan, Handbook of EEG Interpretation. New York City, New York, USA: Demos Medical Publishing, 2007. [9] D. P. Bovet and C. Marco, Understanding the Linux Kernel, 3rd ed. O’Reilly Media, Inc., 2005. https://www.oreilly.com/library/view/understanding-the-linux/0596005652/. [10] V. Shah et al., “The Temple University Hospital Seizure Detection Corpus,” Front. Neuroinform., vol. 12, pp. 1–6, 2018. https://doi.org/10.3389/fninf.2018.00083. [11] F. Pedregosa et al., “Scikit-learn: Machine Learning in Python,” J. Mach. Learn. Res., vol. 12, pp. 2825–2830, 2011. https://dl.acm.org/doi/10.5555/1953048.2078195. [12] J. Gotman, D. Flanagan, J. Zhang, and B. Rosenblatt, “Automatic seizure detection in the newborn: Methods and initial evaluation,” Electroencephalogr. Clin. Neurophysiol., vol. 103, no. 3, pp. 356–362, 1997. https://doi.org/10.1016/S0013-4694(97)00003-9. 
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  9. null (Ed.)
    The goal of this document is to describe the file formats used to store annotations for the Temple University Hospital EEG (TUEG) Corpus (Obeid & Picone, 2016). Subsets of the corpus have been manually annotated (Veloso et al., 2017) and are available from our project web site (Choi et al., 2017). These annotations are stored in two formats: a label file (*.lbl*) that represents an annotation as a hierarchical graph, and a time-synchronous event file (*.tse*) that represents an annotation as a flat series of events with start and stop times, type of seizure, and probability. In this document, we describe each of these formats. Tools to read and display this information are also available from our project web site (Capp et al., 2018; McHugh & Picone, 2016). 
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  10. null (Ed.)
    The goal of this report is to describe to users of the TUH EEG Corpus four important concepts that must be understood to correctly retrieve EEG signals from a data file (e.g., an EDF file). The four key concepts described in this document are: (1) physical placement: the location of the electrodes on the scalp, (2) unipolar montage: the differential recording process used to reduce noise, (3) channel labels: the system used to describe the channels, or digital signals, represented in a computer file and (4) bipolar montages: the differential mapping used to accentuate clinically-relevant events in the signal. This report is not intended to be a primer on the electrophysiology of an EEG, which is a subject unto itself, or a tutorial on how neurologists interpret EEGs. This report simply explains how the signal data in an EEG file must be accessed to accurately support clinical applications (e.g., manual interpretation or annotation of an EEG) and research applications (e.g., automatic interpretation using machine learning). 
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