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Herschede, Sarah R.; Gneid, Hassan; Dent, Taylor; Jaeger, Ellen B.; Lawson, Louise B.; Busschaert, Nathalie (, Organic & Biomolecular Chemistry)An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin.more » « less
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Monasterial, Abigale P.; Hinderks, Calla A.; Viriyavaree, Songkun; Montemore, Matthew M. (, The Journal of Chemical Physics)
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Brakefield, Kyra; Barnes, Justin; Donahue, James P. (, Zeitschrift für Kristallographie - New Crystal Structures)null (Ed.)Abstract C 42 H 68 Cl 4 Mo 6 N 6 S 12 Se 15 , triclinic, P 1̄ (no. 2), a = 13.0196(19) Å, b = 18.813(3) Å, c = 19.745(3) Å, α = 117.446(2)°, β = 99.775(2)°, γ = 98.233(2)°, V = 4091.7(10) Å 3 , Z = 2, R gt ( F ) = 0.0557, wR ref ( F 2 ) = 0.1618, T = 150 K.more » « less
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