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  1. Abstract

    Current experimental vitreous substitutes only replace the physical functions of the natural vitreous humor. Removal of the native vitreous disrupts oxygen homeostasis in the eye, causing oxidative damage to the lens that likely results in cataract formation. Neither current clinical treatments nor other experimental vitreous substitutes consider the problem of oxidative stress after vitrectomy. To address this problem, biomimetic hydrogels are prepared by free radical polymerization of poly(ethylene glycol) methacrylate and poly(ethylene glycol) diacrylate. These hydrogels have similar mechanical and optical properties to the vitreous. The hydrogels are injectable through small‐gauge needles and demonstrate in vitro biocompatibility with human retinal and lens epithelial cells. The hydrogels and added vitamin C, an antioxidant, show a synergistic effect in protecting ocular cells against reactive oxygen species, which fulfills a chemical function of the natural vitreous. These hydrogels have the potential to prevent post‐vitrectomy cataract formation and reduce the cost of additional surgeries.

     
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  2. This study expands on our prior work of the Research Experience for Undergraduates (REU) SITE program to provide data on participant preparation for success in graduate school and their perceptions of the program. In the first two studies from our initial cohort, we summarized that we effectively provided an independent research experience, increased participants perception of preparedness for success in the graduate application process and graduate school and increased their ability to communicate about Biomechanics and Mechanobiology (BMMB)1. In the follow up study we showed that by the end of the program students believed they were better prepared for success in graduate school, two students co-authored publications from their projects, and the majority were enrolled in a graduate program2. Here we share data across our first two cohorts which expands our outcomes associated with graduate school preparation and student perceptions of the REU SITE program. We used our site-licensed online survey tool Qualtrics to administer the surveys for data collection. We used the same pre- and post-survey data to assess changes for both ten student cohorts over the 10-week period. The data were analyzed using a paired t-test from GraphPad Prism 9.3.0 software. This study confirmed the findings from the first two studies while highlighting new information. The new analysis conducted across both cohorts showed participation in the program influenced student interest in applying to graduate school p< 0.05. Additionally, the data show that participants felt more prepared to conduct independent research after participating p<0.05. Of the twenty participants the twelve students who have graduated or will be graduating before summer 2023 are enrolled in a graduate program or have applied for admission. Six of those yet to graduate reported they plan to pursue a graduate degree after completing their BS degree. Additionally, students felt the program prepared them to find and read research articles p<0.01 and participate at a conference p<0.05, skills that will be beneficial for success in a graduate program. Ninety-five percent of the participants indicated the REU SITE met or exceeded their expectations and would recommend the program to others. Similarly, 95% were satisfied with the mentorship of their graduate ambassador and 100% indicated they were satisfied with the mentorship of their faculty. Additionally, we were excited to find that after an adjustment to our program after the first cohort, the second cohort felt prepared to contribute to the field of BMMB p<0.05. This was an objective of the program that was not achieved with the first cohort. Lastly, 85% of participants were from underrepresented minority (URM) backgrounds and 70% were female. Thus, the enrollment of our participants in graduate programs continues to enhance diversity in engineering and the field of BMMB. Going forward we will continue to track the progress of participants and the careers they choose after completion of their graduate degrees. We will also continue to use student feedback to improve the experience for participants. 
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  3. Underrepresented minorities (URM’s) and women comprise 30% and 50% of the U.S. population, respectively. In the Biomedical Engineering (BME) discipline they compose 8% and 37% respectively1. Thus, the enrollment of these groups is still below their representation in society. The BUCKEYE Research Experience for Undergraduates (REU) SITE program aims to help address this disparity by 1.) increasing the number of traditionally underrepresented students pursing a graduate degree and preparing them for success in the application process and graduate school, 2.) providing hands-on scientific research experience in Biomechanics and Mechanobiology (BMMB), 3.) and developing the participants ability to comprehend, contribute, and communicate advances in BMMB. To do this our students participated in a 10-week research immersion where they participated in research, professional development and social activities. Our cohort consisted of ten participants all of whom were from a traditionally underrepresented background and 70% were female. To assess the outcomes from the program we administered survey’s using our site-licensed online survey tool Qualtrics. We used a combination of surveys including pre-and post-surveys to assess program outcomes. Surveys were administered to faculty mentors and participants. The data were analyzed with GraphPad Prism 8.2.1 software using a paired t-test or average. The data indicate that by the end of the program students were conducting independent research p<0.01. Overwhelmingly students believed the program prepared them for success in the application process and graduate school, p<0.04 and p<0.02, respectively. Further, by the end of the program students believed they were better able to communicate about the field of BMMB, p<0.04. Seventy-one percent of faculty mentors who responded to the survey indicated their student produced data that could be included in a future publication. Out of the ten participants four are now enrolled in a graduate program, three are currently applying to one of our graduate programs involved in our REU, and another three are not yet ready to graduate. Therefore, the first four students in our cohort to receive their BS degrees are now enrolled in a graduate program contributing to an increase in representation of underrepresented students. We will continue to track whether the remaining students ultimately apply to or enroll in our or another graduate program and the impact of the REU SITE on our graduate program diversity. Moving forward we will modify our approaches to help participants connect the outcomes of their research to their ability to contribute to the field of BMMB, so they are able to identify with the contributions the faculty mentors have noticed. 
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  4. null (Ed.)
    Underrepresented minorities (URM’s) and women comprise 30% and 50% of the U.S. population, respectively. In the Biomedical Engineering (BME) discipline they compose 8% and37% respectively1. Thus, the enrollment of these groups is still below their representation in society. The BUCKEYE Research Experience for Undergraduates (REU) SITE program aims tohelp address this disparity by 1.) increasing the number of traditionally underrepresented students pursing a graduate degree and preparing them for success in the application process and graduate school, 2.) providing hands-on scientific research experience in Biomechanics and Mechanobiology (BMMB), 3.) and developing the participants ability to comprehend, contribute,and communicate advances in BMMB. To do this our students participated in a 10-week research immersion where they participated in research, professional development and social activities. Our cohort consisted of ten participants all of whom were from a traditionally underrepresented background and 70% were female. To assess the outcomes from the program we administered survey’s using our site-licensed online survey tool Qualtrics. We used a combination of surveys including pre-and post-surveys to assess program outcomes. Surveys were administered to faculty mentors and participants. The data were analyzed with GraphPad Prism 8.2.1 software using a paired t-test or average. The data indicate that by the end of the program students were conducting independent research p<0.01. Overwhelmingly students believed the program prepared them for success in the application process and graduate school, p<0.04 and p<0.02, respectively. Further, by the end of the program students believed they werebetter able to communicate about the field of BMMB, p<0.04. Seventy-one percent of faculty mentors who responded to the survey indicated their student produced data that could be included in a future publication. Out of the ten participants four are now enrolled in a graduate program, three are currently applying to one of our graduate programs involved in our REU, and another three are not yet ready to graduate. Therefore, the first four students in our cohort to receive their BS degrees are now enrolled in a graduate program contributing to an increase in representation of underrepresented students. We will continue to track whether the remaining students ultimately apply to or enroll in our or another graduate program and the impact of the REU SITE on our graduate program diversity. Moving forward we will modify our approaches to help participants connect the outcomes of their research to their ability to contribute to the field of BMMB, so they are able to identify with the contributions the faculty mentors have noticed. 
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