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Abstract Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis. 

Abstract Increasing demand for wearable healthcare synergistically advances the field of electronic textiles, or e‐textiles, allowing for ambulatory monitoring of vital health signals. Despite great promise, the pragmatic deployment of e‐textiles in clinical practice remains challenged due to the lack of a method in producing custom‐designed e‐textiles at high spatial resolution across a large area. To this end, a programmable dual‐regime spray that enables the direct custom writing of functional nanoparticles into arbitrary fabrics at sub‐millimeter resolution over meter scale is employed. The resulting e‐textiles retain the intrinsic fabric properties in terms of mechanical flexibility, water‐vapor permeability, and comfort against multiple uses and laundry cycles. The e‐textiles tightly fit various body sizes and shapes to support the high‐fidelity recording of physiological and electrophysiological signals on the skin under ambulatory conditions. Pilot field tests in a remote health‐monitoring setting with a large animal, such as a horse, demonstrate the scalability and utility of the e‐textiles beyond conventional devices. This approach will be suitable for the rapid prototyping of custom e‐textiles tailored to meet various clinical needs.