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Understanding and predicting turbulent flow phenomena remain a challenge for both theory and applications. The nonlinear and nonlocal character of small-scale turbulence can be comprehensively described in terms of the velocity gradients, which determine fundamental quantities like dissipation, enstrophy, and the small-scale topology of turbulence. The dynamical equation for the velocity gradient succinctly encapsulates the nonlinear physics of turbulence; it offers an intuitive description of a host of turbulence phenomena and enables establishing connections between turbulent dynamics, statistics, and flow structure. The consideration of filtered velocity gradients enriches this view to express the multiscale aspects of nonlinearity and flow structure in a formulation directly applicable to large-eddy simulations. Driven by theoretical advances together with growing computational and experimental capabilities, recent activities in this area have elucidated key aspects of turbulence physics and advanced modeling capabilities.