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  1. Kim, Euishin E (Ed.)
    Background:Early disease detection is emphasized within ophthalmology now more than ever, and as a result, clinicians and innovators turn to deep learning toexpedite accurate diagnosis and mitigate treatment delay. Efforts concentrate on the creation of deep learning systems that analyze clinical imagedata to detect disease-specific features with maximum sensitivity. Moreover, these systems hold promise of early accurate diagnosis and treatmentof patients with common progressive diseases. DenseNet, ResNet, and VGG-16 are among a few of the deep learning Convolutional NeuralNetwork (CNN) algorithms that have been introduced and are being investigated for potential application within ophthalmology. Methods:In this study, the authors sought to create and evaluate a novel ensembled deep learning CNN model that analyzes a dataset of shuffled retinal colorfundus images (RCFIs) from eyes with various ocular disease features (cataract, glaucoma, diabetic retinopathy). Our aim was to determine (1) therelative performance of our finalized model in classifying RCFIs according to disease and (2) the diagnostic potential of the finalized model toserve as a screening test for specific diseases (cataract, glaucoma, diabetic retinopathy) upon presentation of RCFIs with diverse diseasemanifestations. Results:We found adding convolutional layers to an existing VGG-16 model, which was named as a proposed model in this article that, resulted insignificantly increased performance with 98% accuracy (p<0.05), including good diagnostic potential for binary disease detection in cataract,glaucoma, diabetic retinopathy. Conclusion:The proposed model was found to be suitable and accurate for a decision support system in Ophthalmology Clinical Framework. 
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  2. Abstract With the continuous modernization of water plants, the risk of cyberattacks on them potentially endangers public health and the economic efficiency of water treatment and distribution. This article signifies the importance of developing improved techniques to support cyber risk management for critical water infrastructure, given an evolving threat environment. In particular, we propose a method that uniquely combines machine learning, the theory of belief functions, operational performance metrics, and dynamic visualization to provide the required granularity for attack inference, localization, and impact estimation. We illustrate how the focus on visual domain‐aware anomaly exploration leads to performance improvement, more precise anomaly localization, and effective risk prioritization. Proposed elements of the method can be used independently, supporting the exploration of various anomaly detection methods. It thus can facilitate the effective management of operational risk by providing rich context information and bridging the interpretation gap. 
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  3. Adler, John R; Muacevic, A (Ed.)
    This paper investigates the potential of artificial intelligence (AI) and machine learning (ML) to enhance the differentiation of cystic lesions in the sellar region, such as pituitary adenomas, Rathke cleft cysts (RCCs) and craniopharyngiomas (CP), through the use of advanced neuroimaging techniques, particularly magnetic resonance imaging (MRI). The goal is to explore how AI-driven models, including convolutional neural networks (CNNs), deep learning, and ensemble methods, can overcome the limitations of traditional diagnostic approaches, providing more accurate and early differentiation of these lesions. The review incorporates findings from critical studies, such as using the Open Access Series of Imaging Studies (OASIS) dataset (Kaggle, San Francisco, USA) for MRI-based brain research, highlighting the significance of statistical rigor and automated segmentation in developing reliable AI models. By drawing on these insights and addressing the challenges posed by small, single-institutional datasets, the paper aims to demonstrate how AI applications can improve diagnostic precision, enhance clinical decision-making, and ultimately lead to better patient outcomes in managing sellar region cystic lesions. 
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    Free, publicly-accessible full text available December 10, 2025
  4. Furht, Borko; Khoshgoftaar, Taghi (Ed.)
    Acquiring labeled datasets often incurs substantial costs primarily due to the requirement of expert human intervention to produce accurate and reliable class labels. In the modern data landscape, an overwhelming proportion of newly generated data is unlabeled. This paradigm is especially evident in domains such as fraud detection and datasets for credit card fraud detection. These types of data have their own difficulties associated with being highly class imbalanced, which poses its own challenges to machine learning and classification. Our research addresses these challenges by extensively evaluating a novel methodology for synthesizing class labels for highly imbalanced credit card fraud data. The methodology uses an autoencoder as its underlying learner to effectively learn from dataset features to produce an error metric for use in creating new binary class labels. The methodology aims to automatically produce new labels with minimal expert input. These class labels are then used to train supervised classifiers for fraud detection. Our empirical results show that the synthesized labels are of high enough quality to produce classifiers that significantly outperform a baseline learner comparison when using area under the precision-recall curve (AUPRC). We also present results of varying levels of positive-labeled instances and their effect on classifier performance. Results show that AUPRC performance improves as more instances are labeled positive and belong to the minority class. Our methodology thereby effectively addresses the concerns of high class imbalance in machine learning by creating new and effective class labels. 
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    Free, publicly-accessible full text available December 1, 2025
  5. Dong, Jingyan (Ed.)
    This paper introduces a versatile framework crucial for robotic applications such as object manipulation, mobile robot navigation, and pole climbing. It addresses the identification of geometric shapes and dimensions of diverse objects found in varied environments. The proposed method utilizes LiDAR scanning to capture objects from different angles, generating point clouds merged through transformations and superimpositions. After filtering and slicing, intersections are isolated and projected onto a chosen datum plane. The framework employs Non-Linear Least Square fitting via Gauss Newton iterative approach, utilizing pseudo-inverse Jacobian of a hypotrochoid to approximate polygons. The algorithm consecutively fits polygon prisms, determining the best fit with the least norm of error. Results indicate an average least square error of less than 9% for radius fitting and a high f-score for shape identification. 
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    Free, publicly-accessible full text available November 7, 2025
  6. Furht, Borko (Ed.)
    Accurate weight measurement is critical in emergency medicine, particularly for the precise administration of medications and treatments. However, traditional methods of weight estimation can be unreliable, especially in time-sensitive or resource-limited environments. This study provides a comprehensive review of the advancements and techniques in body weight estimation, with a focus on modern approaches leveraging contactless sensors, such as 3D cameras, and AI-powered computational models. The research evaluates the accuracy, reliability, and practical applicability of these methods across different contexts, including healthcare, forensic sciences, and emergency response. Additionally, this study identifies the limitations of current methodologies and uncovers gaps in the literature that warrant further investigation. Our findings aim to guide future research efforts and the development of more precise and scalable weight estimation solutions, ultimately enhancing their applicability in a variety of sectors. 
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  7. Rubin, Stuart; Chen, Shu-Ching (Ed.)
    In this work, we use an unsupervised method for generating binary class labels in a novel context to create class labels for Medicare fraud detection. We examine how class imbalance influences the quality of these new labels and how it affects supervised classification. We use four different Medicare Part D fraud detection datasets, with the largest containing over 5 million instances. The other three datasets are sampled from the original dataset. Using Random Under-Sampling (RUS), we subsample from the majority class of the original data to produce three datasets with varying levels of class imbalance. To evaluate the performance of the newly created labels, we train a supervised classifier and evaluate its classification performance and compare it to an unsupervised anomaly detection method as a baseline. Our empirical findings indicate that the generated class labels are of high enough quality and enable effective supervised classifier training for fraud detection. Additionally, supervised classification with the new labels consistently outperforms the baseline used for comparison across all test scenarios. Further more, we observe an inverse relationship between class imbalance in the dataset and classifier performance, with AUPRC scores improving as the training dataset becomes more balanced. This work not only validates the efficacy of the synthesized class labels in labeling Medicare fraud but also shows its robustness across different degrees of class imbalance. 
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  8. Furht, Borko (Ed.)
    With the ongoing expansion of the aging population, it is increasingly critical to prioritize the safety of older drivers. The objective of this study is to utilize sensor data in order to detect early indications of impairment, thereby facilitating proactive interventions and enhancing road safety for the elderly. This article provides an overview of the research approach, presents significant results, and analyzes the consequences of utilizing in-vehicle sensors i.e. vision and telematics, to mitigate cognitive decline among elderly drivers; in doing so, it promotes progress in the domains of public health and transportation safety by standardizing the use of such devices to automatically assess the drivers’ cognitive functions. 
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  9. The flourishing realm of advanced driver-assistance systems (ADAS) as well as autonomous vehicles (AVs) presents exceptional opportunities to enhance safe driving. An essential aspect of this transformation involves monitoring driver behavior through observable physiological indicators, including the driver’s facial expressions, hand placement on the wheels, and the driver’s body postures. An artificial intelligence (AI) system under consideration alerts drivers about potentially unsafe behaviors using real-time voice notifications. This paper offers an all-embracing survey of neu ral network-based methodologies for studying these driver bio-metrics, presenting an exhaustive examination of their advantages and drawbacks. The evaluation includes two relevant datasets, separately categorizing ten different in-cabinet behaviors, providing a systematic classification for driver behaviors detection. The ultimate aim is to inform the development of driver behavior monitoring systems. This survey is a valuable guide for those dedicated to enhancing vehicle safety and preventing accidents caused by careless driving. The paper’s structure encompasses sections on autonomous vehicles, neural networks, driver behavior analysis methods, dataset utilization, and final findings and future suggestions, ensuring accessibility for audiences with diverse levels of understanding regarding the subject matter. 
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  10. Saif, Mehrdad (Ed.)
    This study explores cutting-edge computational technologies and intelligent methods to create realistic synthetic data, focusing on dementia-centric Magnetic Resonance Imaging (MRI) scans related to Alzheimer’s and Parkinson’s diseases. The research delves into Generative Adversarial Networks (GANs), Variational Autoencoders, and Diffusion Models, comparing their efficacy in generating synthetic MRI scans. Using datasets from Alzheimer’s and Parkinson’s patients, the study reveals intriguing findings. In the Alzheimer dataset, diffusion models produced non-dementia images with the lowest Frechet Inception Distance (FID) score at 92.46, while data-efficient GANs excelled in generating dementia images with an FID score of 178.53. In the Parkinson dataset, data-efficient GANs achieved remarkable FID scores of 102.71 for dementia images and 129.77 for non-dementia images. The study also introduces a novel aspect by incorporating a classification study, validating the generative metrics. DenseNets, a deep learning architecture, exhibited superior performance in disease detection compared to ResNets. Training both models on images generated by diffusion models further improved results, with DenseNet achieving accuracies of 80.84% and 92.42% in Alzheimer’s and Parkinson’s disease detection, respectively. The research not only presents innovative generative architectures but also emphasizes the importance of classification metrics, providing valuable insights into the synthesis and detection of neurodegenerative diseases through advanced computational techniques. 
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