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Local stresses in a tissue, a collective property, links cell division and dynamics. 

A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity (η) of a non-confluent embryonic tissue grows sharply until a critical cell packing fraction (ϕ_S). The increase inηup toϕ_Sis similar to the behavior observed in several glass-forming materials, which suggests that the cell dynamics is sluggish or glass-like. Surprisingly,ηis a constant aboveϕ_S. To determine the mechanism of this unusual dependence ofηonϕ, we performed extensive simulations using an agent-based model of a dense non-confluent two-dimensional tissue. We show that polydispersity in the cell size, and the propensity of the cells to deform, results in the saturation of the available free area per cell beyond a critical packing fraction. Saturation in the free space not only explains the viscosity plateau aboveϕ_Sbut also provides a relationship between equilibrium geometrical packing to the dramatic increase in the relaxation dynamics.