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Award ID contains: 2316218

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  1. ; ; ; ; ; ; ; ; ; ; et al (, microPublication biology)
    In Drosophila melanogaster genetic screens are often used to identify genes associated with different biological processes. Here, we have utilized the Flp/FRT system to generate mitotic clones within the developing eye. These clones were screened for mutations that disrupt cell division, organ patterning, and cell growth. One such mutation from this screen, mutant M.3.2, resulted in an expansion of the cuticle within the area normally covered by ommatidium as well as an overall smaller eye size. Genetic and molecular mapping revealed this mutation to be in the gene, tout-velu (ttv). 
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    Free, publicly-accessible full text available January 1, 2026
  2. ; ; ; ; ; ; ; ; ; ; et al (, microPublication biology)
    The multi-institutional Fly-CURE project is an undergraduate genetics research initiative centered on Drosophila melanogaster as a model organism. This study aimed to characterize and map mutations discovered through a Flp/FRT EMS screen to investigate complex interactions among genes associated with cell division, growth, and apoptosis leading to abnormal cell proliferation. The F.1.1 mosaic phenotype resulted in a rough eye phenotype with an overall decrease in representation of mutant tissue. To genetically map the location of the F.1.1 mutation, flies with genotype FRT42D,F.1.1,Dark82/CyO were crossed with the Bloomington 2R Deficiency Kit. The resultant F1 progeny were analyzed to pinpoint mapping deficiencies. The genomic region containing the Patronin gene was identified and sequencing confirmed the novel allele of PatroninF.1.1. 
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    Free, publicly-accessible full text available January 1, 2026
  3. ; ; ; ; ; ; ; ; ; ; et al (, microPublication biology)
    Genetic screens in Drosophila melanogaster have long been used to identify genes found in a variety of developmental, cellular, and behavioral processes. Here we describe the characterization and mapping of a mutation identified in a conditional screen for genetic regulators of cell growth and cell division. Within a Flp/FRT system, mutant G.3.2 results in a reduction of mutant tissue and a rough eye phenotype. We find that G.3.2 maps to the gene cnk, providing further support that cnk is a critical gene in Drosophila eye development. This mutant was characterized, mapped and sequenced by undergraduate students within the Fly-CURE consortium. 
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