More Like this

1. Acyclic Twisted Amides

   https://doi.org/10.1021/acs.chemrev.1c00225  

   Meng, Guangrong; Zhang, Jin; Szostak, Michal (October 2021, Chemical Reviews)
2. Synthesis of Amides by Transamidation and Amidation of Activated Amides and Esters

   Li, Guangchen; Szostak, Michal (January 2020, Science of synthesis)

   This chapter provides a summary of the recent advances in direct transamidation and amidation reactions of activated amides and esters via transition- metal-catalyzed and transition-metal-free C(acyl)–N and C(acyl)–O bond cleavage as a new disconnection for the synthesis of amide bonds. 

   more » « less
3. Decarbonylative cross-coupling of amides

   https://doi.org/10.1039/c8ob01832d  

   Liu, Chengwei; Szostak, Michal (November 2018, Organic & Biomolecular Chemistry)

   Cross-coupling reactions are among the most powerful C–C and C–X bond forming tools in organic chemistry. Traditionally, cross-coupling methods rely on the use of aryl halides or pseudohalides as electrophiles. In the past three years, decarbonylative cross-couplings of amides have emerged as an attractive method for the construction of a wide variety of carbon–carbon and carbon–heteroatom bonds, allowing for the synthetically-valuable functional group inter-conversion of the amide bond. These previously elusive reactions hinge upon selective activation of the N–C(O) acyl amide bond, followed by CO extrusion, in a formal double N–C/C–C bond activation, to generate a versatile aryl–metal intermediate as an attractive alternative to traditional cross-couplings of aryl halides and pseudohalides. In this perspective review, we present recent advances and key developments in the field of decarbonylative cross-coupling reactions of amides as well as discuss future challenges and potential applications for this exciting field. 

   more » « less
4. N -Methylamino Pyrimidyl Amides (MAPA): Highly Reactive, Electronically-Activated Amides in Catalytic N–C(O) Cleavage

   https://doi.org/10.1021/acs.orglett.7b02288  

   Meng, Guangrong; Lalancette, Roger; Szostak, Roman; Szostak, Michal (August 2017, Organic Letters)
5. Fungicidal Properties of Some Novel Trifluoromethylphenyl Amides

   https://doi.org/10.1002/cbdv.201800618  

   Tsikolia, Maia; Bernier, Ulrich R.; Wedge, David E.; Tabanca, Nurhayat; Abboud, Khalil A.; Linthicum, Kenneth J. (May 2019, Chemistry & Biodiversity)

   null (Ed.)