- NSF-PAR ID:
- 10056241
- Date Published:
- Journal Name:
- Chemical Science
- Volume:
- 9
- Issue:
- 7
- ISSN:
- 2041-6520
- Page Range / eLocation ID:
- 1836 to 1845
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract Two limiting cases of molecular recognition, induced fit (IF) and conformational selection (CS), play a central role in allosteric regulation of natural systems. The IF paradigm states that a substrate “instructs” the host to change its shape after complexation, while CS asserts that a guest “selects” the optimal fit from an ensemble of preexisting host conformations. With no studies that quantitatively address the interplay of two limiting pathways in abiotic systems, we herein and for the first time describe the way by which twisted capsule
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