More Like this

1. Laser Fabrication of Polymeric Microneedles for Transdermal Drug Delivery

   Aldawood, Faisal ; Desai, Salil ; Andar, Abhay ( January 2021 , Proceedings of the 2021 IISE Annual Conference)

   Microneedles provide a transdermal pathway for drug delivery, cosmetic infusion, vaccine administration, and disease diagnostics. Microneedle fabrication relies on the interplay of several variables which include design parameters, material properties, and processing conditions. In this research, our group explores the effect of design parameters and process variables for laser ablation of microneedles within a Polymethyl methacrylate (PMMA) mold. An Ytterbium laser (200W) was utilized to study the effect of five inputs factors (laser power, pulse width, number of repetitions, laser waveform, and interval time between laser pulses) on two output factors (diameter and height) of the fabricated microneedles. Polydimethylsiloxane (PDMS) polymer was cast within the PMMA microneedle mold. Scanning electron microscopy (SEM) was employed to image topographical features of the microneedles. Further, mechanical testing of the microneedles was conducted to evaluate the buckling load and deformation behavior of the microneedle array. A 20W pulse laser with trapezoidal waveform resulted in optimal microneedle topography with an aspect ratio of 1.2. ANOVA results (α = 0.05) depicted that laser power and number of repetitions were significant factors determining the geometrical features of the microneedle array. This research establishes a framework for the design and manufacturing of customized microneedles for precision medicine.
2. Dynamical Methods for Studying Noise in Frequency Comb Sources

   Menyuk, Curtis R. ; Wang, Shaokang ( March 2022 , Twelfth IMACS International Conference on Nonlinear Evolution Equations and Wave Phenomena: Computation and Theory,)

   Frequency combs have revolutionized the measurement of time and frequency since their invention in 2000, and have a wide array of applications to applications that range from basic science applications, to a wide array of sensing applications, to commercial applications, to military applications, and the list goes on. Noise poses a fundamental limit to these systems, and calculating its impact play a critical role in system design. Frequency combs are created by modelocked laser systems that emit a periodic train of short pulses. Laser systems are complex nonlinear systems and the usual method for determining the impact of noise is to carry out computationally-expensive Monte Carlo methods. That limits the parameter range over which it is possible to study the noise impact. We have developed a new approach based on dynamical systems methods. In our approach, we determine a stationary state of the laser system as parameters vary solving a root-finding problem [Wang1]. Starting from a stationary state, we determine all the eigenvalues and eigenvalues of the linearized system. The variance of the amplitudes of the eigenvalues obey either random walk of Langevin equations [Menyuk]. Starting from that point, we can determine the power spectral density of the key lasermore »parameters (amplitude jitter, timing jitter, frequency jitter, phase jitter) [Wang2]. We applied this approach to SESAM lasers and found that we were able to reproduce a computation that took 20 minutes on a cluster with 256 cores with a computation that took less than 4 minutes on a desktop computer.« less
3. An efficient 2D array of blue-detuned optical traps

   Graham, Trent ; Xiaoyu, Jiang ; Poole, Cody ; Sun, Yuan ; Lichtman, Martin ; Saffman, Mark ( May 2018 , Bulletin American Physical Society, DAMOP 2018)

   We demonstrate a 2D lattice of blue-detuned optical traps which uses laser power efficiently, is tolerant to perturbations in beam alignment, and is insensitive to interferometric phases. Blue traps have several advantages over red traps despite requir- ing a more complicated beam geometry. Since atoms in a blue trap sit at an intensity minimum, Stark shift noise and site-to-site calibrations are minimized. However, constructing a blue lattice which efficiently con- verts laser power into trap depth, is challenging. For example, a lattice of bottle beams is inefficient because neighboring sites are separated by two walls, limiting the number of traps that can be formed. An array of tightly spaced Gaussian beams is a more efficient blue trap, but the trap potentials are susceptible to alignment perturbations. We demonstrate an array which uses diffractive optical elements to create a cross-hatched pattern of lines in the focal region where the atoms are trapped in up to 121 sites. This "line array" is almost twice as efficient as the Gaussian beam array and is more resilient to perturbations in beam alignment.
4. Self-limiting electrospray deposition on polymer templates

   https://doi.org/10.1038/s41598-020-74146-1  

   Lei, Lin ; Gamboa, Arielle R. ; Kuznetsova, Christianna ; Littlecreek, Sunshine ; Wang, Jingren ; Zou, Qingze ; Zahn, Jeffrey D. ; Singer, Jonathan P. ( December 2020 , Scientific Reports)

   Abstract Electrospray deposition (ESD) applies a high voltage to liquids flowing through narrow capillaries to produce monodisperse generations of droplets down to hundreds of nanometers in diameter, each carrying a small amount of the delivered solute. This deposition method has been combined with insulated stencil masks for fabricating micropatterns by spraying solutions containing nanoparticles, polymers, or biomaterials. To optimize the fabrication process for micro-coatings, a self-limiting electrospray deposition (SLED) method has recently been developed. Here, we combine SLED with a pre-existing patterned polymer film to study SLED’s fundamental behavior in a bilayer geometry. SLED has been observed when glassy insulating materials are sprayed onto conductive substrates, where a thickness-limited film forms as charge accumulates and repels the arrival of additional charged droplets. In this study, polystyrene (PS), Parylene C, and SU-8 thin films of varying thickness on silicon are utilized as insulated spraying substrates. Polyvinylpyrrolidone (PVP), a thermoplastic polymer is sprayed below its glass transition temperature (T g ) to investigate the SLED behavior on the pre-deposited insulating films. Furthermore, to examine the effects of in-plane confinement on the spray, a microhole array patterned onto the PS thin film by laser dewetting was sprayed with dyed PVP in the SLEDmore »mode. This was then extended to an unmasked electrode array showing that masked SLED and laser dewetting could be used to target microscale regions of conventionally-patterned electronics.« less
5. An optimised gravitational wave follow-up strategy with the Australian Square Kilometre Array Pathfinder

   https://doi.org/10.1017/pasa.2019.9  

   Dobie, D. ; Murphy, T. ; Kaplan, D. L. ; Ghosh, S. ; Bannister, K. W. ; Hunstead, R. W. ( January 2019 , Publications of the Astronomical Society of Australia)

   Abstract The detection of a neutron star merger by the Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo gravitational wave detectors, and the subsequent detection of an electromagnetic counterpart have opened a new era of transient astronomy. With upgrades to the Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo detectors and new detectors coming online in Japan and India, neutron star mergers will be detected at a higher rate in the future, starting with the O3 observing run which will begin in early 2019. The detection of electromagnetic emission from these mergers provides vital information about merger parameters and allows independent measurement of the Hubble constant. The Australian Square Kilometre Array Pathfinder is expected to become fully operational in early 2019, and its 30 deg 2 field of view will enable us to rapidly survey large areas of sky. In this work we explore prospects for detecting both prompt and long-term radio emission from neutron star mergers with Australian Square Kilometre Array Pathfinder and determine an observing strategy that optimises the use of telescope time. We investigate different strategies to tile the sky with telescope pointings in order to detect radio counterparts with limited observing time, using 475 simulated gravitationalmore »wave events. Our results show a significant improvement in observing efficiency when compared with a naïve strategy of covering the entire localisation above some confidence threshold, even when achieving the same total probability covered.« less