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   https://doi.org/10.1039/C8NJ01139G  

   Xing, Xiaoyu; Zhao, Yan (January 2018, New Journal of Chemistry)

   The molecular recognition unit of a fluorescent sensor is its most cumbersome part to design and synthesize, but is key to the specificity of the sensor. Molecular imprinting within cross-linked micelles using easily synthesized modular templates allowed us to create analyte-specific binding sites with a nearby fluorescent probe. This strategy makes it straightforward to vary the recognition unit independent of the reporting unit, making the sensor potentially applicable to a wide range of molecular analytes. 

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2. Ultrafast excited-state proton transfer dynamics in dihalogenated non-fluorescent and fluorescent GFP chromophores

   https://doi.org/10.1063/1.5138666  

   Chen, Cheng; Zhu, Liangdong; Boulanger, Sean A.; Baleeva, Nadezhda S.; Myasnyanko, Ivan N.; Baranov, Mikhail S.; Fang, Chong (January 2020, The Journal of Chemical Physics)
3. Ultrabright fluorescent nanothermometers

   https://doi.org/10.1039/D1NA00449B  

   Kalaparthi, V.; Peng, B.; Peerzade, S. A.; Palantavida, S.; Maloy, B.; Dokukin, M. E.; Sokolov, I. (August 2021, Nanoscale Advances)

   Here we report on the first ultrabright fluorescent nanothermometers, ∼50 nm-size particles, capable of measuring temperature in 3D and down to the nanoscale. The temperature is measured through the recording of the ratio of fluorescence intensities of fluorescent dyes encapsulated inside the nanochannels of the silica matrix of each nanothermometer. The brightness of each particle excited at 488 nm is equivalent to the fluorescence coming from 150 molecules of rhodamine 6G and 1700 molecules of rhodamine B dyes. The fluorescence of both dyes is excited with a single wavelength due to the Förster resonance energy transfer (FRET). We demonstrate repeatable measurements of temperature with the uncertainty down to 0.4 K and a constant sensitivity of ∼1%/K in the range of 20–50 °C, which is of particular interest for biomedical applications. Due to the high fluorescence brightness, we demonstrate the possibility of measurement of accurate 3D temperature distributions in a hydrogel. The accuracy of the measurements is confirmed by numerical simulations. We further demonstrate the use of single nanothermometers to measure temperature. As an example, 5–8 nanothermometers are sufficient to measure temperature with an error of 2 K (with the measurement time of >0.7 s). 

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4. Chemoselective and Enantioselective Fluorescent Recognition of Prolinol

   https://doi.org/10.1021/acs.joc.2c02152  

   Jiang, Yixuan; Tian, Jun; Guo, Hongyu; Gong, Yan; Yu, Shanshan; Yu, Xiaoqi; Pu, Lin (January 2023, The Journal of Organic Chemistry)
5. Smart fluorescent polysaccharides: Recent developments and applications

   https://doi.org/10.1016/j.carbpol.2023.121471  

   Novo, Diana C.; Edgar, Kevin J. (January 2024, Carbohydrate Polymers)

   Polysaccharides are ubiquitous, generally benign in nature, and compatible with many tissues in biomedical situations, making them appealing candidates or new materials such as therapeutic agents and sensors. Fluorescent labeling can create the ability to sensitively monitor distribution and transport o polysaccharide-based materials, which can or example urther illuminate drug-delivery mechanisms and thereore improve design o delivery systems. Herein, we review uorophore selection and ways o appending polysaccharides, utility o the product uorescent polysaccharides as new smart materials, and their stimulus-responsive nature, with ocus on their biomedical applications as environment-sensitive biosensors, imaging, and as molecular rulers. Further, we discuss the advantages and disadvantages o these methods, and uture prospects or creation and use o these sel-reporting materials. 

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