The development of synthetic, metal-based catalysts to perform intracellular bioorthogonal reactions represents a relatively new and important area of research that combines transition metal catalysis and chemical biology. The ability to perform reactions in cellulo , especially those transformations without a natural counterpart, offers a versatile tool for medicinal chemists and chemical biologists. With proper modification of the metal catalysts, it is even possible to direct a reaction to certain intracellular sites. This review highlights advances in this new area, from early work on intracellular functional group conversions to recent advances in intracellular synthesis of drugs, including cytotoxic agents. Both the fundamental and applied aspects of this approach to intracellular synthesis are reviewed.
Progress in catalytic synthesis of advanced carbon nanofibers
Carbon nanofibers (CNFs) have wide applications in various high-tech areas. The demand for CNFs can exponentially increase due to the rapid development of advanced functional materials. Accordingly, a transformational progress is being made in synthesizing CNFs, especially functionalized CNFs. A dominant CNF synthesis pathway is catalytic chemical vapor deposition (CCVD). Therefore, the goal of this work is to review the most recent progress in CCVD synthesis of functional CNFs and to understand how the process conditions and catalysts, especially metal catalysts, affect the physical and chemical properties of the produced CNFs.
- Award ID(s):
- 1632899
- Publication Date:
- NSF-PAR ID:
- 10091652
- Journal Name:
- Journal of Materials Chemistry A
- Volume:
- 5
- Issue:
- 27
- Page Range or eLocation-ID:
- 13863 to 13881
- ISSN:
- 2050-7488
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Publisher's Version of Record
- https://doi.org/10.1039/C7TA02007D
