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1. Effects of shortening velocity on the stiffness to force ratio during isometric force redevelopment suggest mechanisms of residual force depression

   https://doi.org/10.1038/s41598-023-28236-5  

   Jeong, Siwoo ; Nishikawa, Kiisa ( January 2023 , Scientific Reports)

   Although the phenomenon of residual force depression has been known for decades, the mechanisms remain elusive. In the present study, we investigated mechanisms of residual force depression by measuring the stiffness to force ratio during force redevelopment after shortening at different velocities. The results showed that the slope of the relationship between muscle stiffness and force decreased with decreasing shortening velocity, and the y-intercept increased with decreasing shortening velocity. The differing slopes and y-intercepts indicate that the stiffness to force ratio during isometric force redevelopment depends on the active shortening velocity at a given muscle length and activation level. The greater stiffness to force ratio after active shortening can potentially be explained by weakly-bound cross bridges in the new overlap zone. However, weakly-bound cross bridges are insufficient to explain the reduced slope at the slowest shortening velocity because the reduced velocity should increase the proportion of weakly- to strongly-bound cross bridges, thereby increasing the slope. In addition, if actin distortion caused by active shortening recovers during the force redevelopment period, then the resulting slope should be similar to the non-linear slope of force redevelopment over time. Alternatively, we suggest that a tunable elastic element, such as titin, could potentiallymore »explain the results.

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   Wang, Jingren ; Zou, Qingze ( April 2020 , IEEE/ASME Transactions on Mechatronics)
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   Jakob, Devon S. ; Wang, Haomin ; Xu, Xiaoji G. ( April 2020 , ACS Nano)
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   https://doi.org/10.1021/acsnano.7b05721  

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