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Abstract Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To address the unmet need for vastly prolonged E2 release, we report first-generation poly(pro-E2) biomaterial scaffolds that release E2 at nanomolar concentrations over the course of 1–10 years via slow hydrolysis in vitro. As a result of their finely tuned properties, these scaffolds demonstrate the ability to promote and guide neurite extension ex vivo and protect neurons from oxidative stress in vitro. The design and testing of these materials reported herein demonstrate the first step towards next-generation implantable biomaterials with prolonged release and excellent regenerative potential.
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E_2-cells and mapping class groups
We prove a new kind of stabilisation result, “secondary homological stability,” for the homology of mapping class groups of orientable surfaces with one boundary component. These results are obtained by constructing CW approximations to the classifying spaces of these groups, in the category of E2-algebras, which have no E2-cells below a certain vanishing line.
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- Award ID(s):
- 1803766
- PAR ID:
- 10100871
- Date Published:
- Journal Name:
- Publications mathématiques de l'IHÉS
- ISSN:
- 0073-8301
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1007/s10240-019-00107-8
