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Abstract With advances in biomedical research, biomarkers are becoming increasingly important prognostic factors for predicting overall survival, while the measurement of biomarkers is often censored due to instruments' lower limits of detection. This leads to two types of censoring: random censoring in overall survival outcomes and fixed censoring in biomarker covariates, posing new challenges in statistical modeling and inference. Existing methods for analyzing such data focus primarily on linear regression ignoring censored responses or semiparametric accelerated failure time models with covariates under detection limits (DL). In this paper, we propose a quantile regression for survival data with covariates subject to DL. Comparing to existing methods, the proposed approach provides a more versatile tool for modeling the distribution of survival outcomes by allowing covariate effects to vary across conditional quantiles of the survival time and requiring no parametric distribution assumptions for outcome data. To estimate the quantile process of regression coefficients, we develop a novel multiple imputation approach based on another quantile regression for covariates under DL, avoiding stringent parametric restrictions on censored covariates as often assumed in the literature. Under regularity conditions, we show that the estimation procedure yields uniformly consistent and asymptotically normal estimators. Simulation results demonstrate the satisfactory finite‐sample performance of the method. We also apply our method to the motivating data from a study of genetic and inflammatory markers of Sepsis.
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Calibrated percentile double bootstrap for robust linear regression inference
We consider inference for the parameters of a linear model when the covariates are random and the relationship between response and covariates is possibly non-linear. Conventional inference methods such as z intervals perform poorly in these cases. We propose a double bootstrap-based calibrated percentile method, perc-cal, as a general-purpose CI method which performs very well relative to alternative methods in challenging situations such as these. The superior performance of perc-cal is demonstrated by a thorough, full-factorial design synthetic data study as well as a data example involving the length of criminal sentences. We also provide theoretical justification for the perc-cal method under mild conditions. The method is implemented in the R package "perccal", available through CRAN and coded primarily in C++, to make it easier for practitioners to use.
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- PAR ID:
- 10128892
- Date Published:
- Journal Name:
- Statistica sinica
- Volume:
- 28
- ISSN:
- 1017-0405
- Page Range / eLocation ID:
- 2565-2589
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/doi:10.5705/ss.202016.0546
