skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: On the Preservation of Non-covalent Peptide Assemblies in a Tandem-Trapped Ion Mobility Spectrometer-Mass Spectrometer (TIMS-TIMS-MS)
Award ID(s):
1654608
PAR ID:
10139857
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Journal of The American Society for Mass Spectrometry
Volume:
30
Issue:
7
ISSN:
1044-0305
Page Range / eLocation ID:
1204 to 1212
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. We document the performance of new ATONA (‘aA to nA’) amplifiers installed on an Isotopx Phoenix thermal ionisation mass spectrometer (TIMS) at Princeton University and evaluate their suitability for high-precision analyses of Pb and U isotopes in pg- to ng-size samples characteristic for U–Pb geochronology. The new amplifiers are characterised by low and stable noise levels comparable to 10 12 to 10 13 ohm resistors, response time <0.5 s, exceptional gain stability <1 ppm and a vast dynamic range theoretically allowing to quantify signals from aA (10 −18 A) to nA (10 −9 A) level. We measured a set of Pb standards, synthetic U–Pb solutions and natural zircons at currents of 2 × 10 −16 to 2 × 10 −12 A (corresponding to intensities of 20 μV to 200 mV relative to a 10 11 ohm amplifier) to assess the utility of ATONA in replacing ion counting for the smallest samples. The results show a clear precision benefit of using ATONA-Faraday detection over Daly ion counting for ion currents of >10 −14 A (1 mV relative to a 10 11 ohm amplifier or ca. 60 kcps). As such currents are routinely achievable for major Pb peaks of interest ( 205–208 Pb) in natural samples containing more than ca. 10 pg Pb* (radiogenic Pb), we expect ATONA-Faraday detection to find broad applications in U–Pb geochronology. Its practical use for low-blank, radiogenic samples continues to require ion counting for 204 Pb, either with a fixed Faraday–ion counter gain or using a dynamic two-step ( e.g. FaraDaly) method. Routine adoption of ATONA-Faraday collection in place of ion counting for most major Pb and U isotopes has the potential to increase sample throughput and precision, both improving the accessibility of isotope dilution (ID)-TIMS geochronology and pushing this technique towards better reproducibility. 
    more » « less
  2. The serpentine integrated grating spectrometer uses a meandering delay line and outcoupling grating rows to implement a crossed-dispersion wide-bandwidth integrated spectrometer with resolving power of 10 5 and 10 4 spectral bins in a few cm 3 volume. 
    more » « less
  3. We present the design of a pair spectrometer for use at FACET-II, where there is a need for spectroscopy of photons having energies up to 10 GeV. Incoming gammas are converted to high-energy positron-electron pairs, which are then subsequently analyzed in a dipole magnet. These charged particles are then recorded in arrays of acrylic Cherenkov counters, which are significantly less sensitive to background x-rays than scintillator counters in this case. To reconstruct energies of single high-energy photons, the spectrometer has a sensitivity to single positron-electron pairs. Even in this single-photon limit, there is always some low-energy continuum present, so spectral deconvolution is not trivial, for which we demonstrate a maximum likelihood reconstruction. Finally, end-to-end simulations of experimental scenarios, together with anticipated backgrounds, are presented. 
    more » « less