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1. Crystal structure of 1 H -imidazole-1-methanol

   https://doi.org/10.1107/S2056989022002614  

   Wysocki, Megan M.; Puzovic, Gorana; Dowell, Keith L.; Reinheimer, Eric W.; Gerlach, Deidra L. (April 2022, Acta Crystallographica Section E Crystallographic Communications)

   The synthesis and the crystal structure of 1 H -imidazole-1-methanol, C 4 H 6 N 2 O, are described. This compound comprises an imidazole ring with a methanol group attached at the 1-position affording an imine nitrogen atom able to receive a hydrogen bond and an alcohol group able to donate to a hydrogen bond. This imidazole methanol crystallizes with monoclinic ( P 2 1 / n ) symmetry with three symmetry-unique molecules. These three molecules are connected via O—H...N hydrogen bonding in a head-to-tail configuration to form independent three-membered macrocycles. 

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2. Crystal structure of 1-(2,6-diisopropylphenyl)-1 H -imidazole

   https://doi.org/10.1107/S2056989023009179  

   Dudeja, Neil; Arreaga, Briana C; Brannon, Jacob P; Stieber, S_Chantal E (November 2023, Acta Crystallographica Section E Crystallographic Communications)

   The crystal structure of the title compound, C₁₅H₂₀N₂or^DippIm, is reported. At 106 (2) K, the molecule has monoclinicP2₁/c symmetry with four molecules in the unit cell. The imidazole ring is rotated 80.7 (1)° relative to the phenyl ring. Intermolecular stabilization primarily results from close contacts between the N atom at the 3-position on the imidazole ring and the C—H bond at the 4-position on the neighboring^DippIm, with aryl–aryl distances outside of the accepted distance of 5 Å for π-stacking. 

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3. Superconductivity and Pronounced Electron‐Phonon Coupling in Rock‐Salt Al _1−x O _1−x and Ti _1−x O _1−x

   https://doi.org/10.1002/aelm.202400141  

   Žguns, Pjotrs; Gedik, Nuh; Yildiz, Bilge; Li, Ju (May 2024, Advanced Electronic Materials)

   Abstract The highest ambient‐pressure Tc among binary compounds is 40 K (MgB2). Higher Tc is achieved in high‐pressure hydrides or multielement cuprates. Alternatively, are explored superconducting properties of binary, metastable sub‐oxides, that may emerge under extremely low oxygen partial pressure. The emphasis is on the rock‐salt structure, which is known to promote superconductivity, and exploring AlO, ScO, TiO, and NbO. Dynamic lattice stability is achieved by introducing metal and oxygen vacancies in the fashion of Nb_1−xO_1−x‐type structure (x = ¼). The electron‐phonon (e‐ph) coupling is remarkably large in Al_1−xO_1−xand Ti_1−xO_1−x(λ ≈ 2 at x = ¼), with Tc ≈ 35 K according to the Allen–Dynes equation. Significantly, the coupling strength is comparable to that in high‐pressure hydrides, yet, in contrast to hydrides and MgB2, the coupling is largely driven by low frequency phonons. Sc_1−xO_1−xand Nb_1−xO_1−xshow significantly smaller λ and Tc. Further, hydrogen intercalation to boost λ and Tc is investigated. Only Ti_1−x(O_1−xHx) and Nb_1−x(O_1−xHx) are dynamically stable upon intercalation, where H, respectively, decreases and increases Tc. The effect of H doping on electronic structure and Tc is discussed. Altogether, the study suggests that metal sub‐oxides are promising compounds to achieve strong e‐ph coupling at ambient pressure. 

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4. Maximal Tori in HH 1 and the Fundamental Group

   https://doi.org/10.1093/imrn/rnac026  

   Briggs, Benjamin; Rubio y Degrassi, Lleonard (March 2023, International Mathematics Research Notices)

   Abstract We investigate maximal tori in the Hochschild cohomology Lie algebra $${\operatorname {HH}}^1(A)$$ of a finite dimensional algebra $$A$$, and their connection with the fundamental groups associated to presentations of $$A$$. We prove that every maximal torus in $${\operatorname {HH}}^1(A)$$ arises as the dual of some fundamental group of $$A$$, extending the work by Farkas, Green, and Marcos; de la Peña and Saorín; and Le Meur. Combining this with known invariance results for Hochschild cohomology, we deduce that (in rough terms) the largest rank of a fundamental group of $$A$$ is a derived invariant quantity, and among self-injective algebras, an invariant under stable equivalences of Morita type. Using this we prove that there are only finitely many monomial algebras in any derived equivalence class of finite dimensional algebras; hitherto this was known only for very restricted classes of monomial algebras. 

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5. The Gene scb-1 Underlies Variation in Caenorhabditis elegans Chemotherapeutic Responses

   https://doi.org/10.1534/g3.120.401310  

   Evans, Kathryn S.; Andersen, Erik C. (May 2020, G3: Genes|Genomes|Genetics)

   Pleiotropy, the concept that a single gene controls multiple distinct traits, is prevalent in most organisms and has broad implications for medicine and agriculture. The identification of the molecular mechanisms underlying pleiotropy has the power to reveal previously unknown biological connections between seemingly unrelated traits. Additionally, the discovery of pleiotropic genes increases our understanding of both genetic and phenotypic complexity by characterizing novel gene functions. Quantitative trait locus (QTL) mapping has been used to identify several pleiotropic regions in many organisms. However, gene knockout studies are needed to eliminate the possibility of tightly linked, non-pleiotropic loci. Here, we use a panel of 296 recombinant inbred advanced intercross lines of Caenorhabditis elegans and a high-throughput fitness assay to identify a single large-effect QTL on the center of chromosome V associated with variation in responses to eight chemotherapeutics. We validate this QTL with near-isogenic lines and pair genome-wide gene expression data with drug response traits to perform mediation analysis, leading to the identification of a pleiotropic candidate gene, scb-1 for some of the eight chemotherapeutics. Using deletion strains created by genome editing, we show that scb-1 , which was previously implicated in response to bleomycin, also underlies responses to other double-strand DNA break-inducing chemotherapeutics. This finding provides new evidence for the role of scb-1 in the nematode drug response and highlights the power of mediation analysis to identify causal genes. 

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