This paper analyzes the scalp electroencephalogram (EEG) recorded from 14 human subjects with pFC lesions and 20 healthy controls while performing lateral visuospatial working memory tasks to identify the directional brain networks responsible for memory encoding. First, we show that effective connectivity features using directed information (DI) are more accurate and robust than the functional connectivity measure of correlation coefficients in classifying the memory encoding stage from the pretrial phase, with a mean accuracy of 99.36%. Second, we identify the functional segregation of memory encoding to a much smaller sub-network by showing that the top 2.5% of the observed DI features can distinguish memory encoding from the pretrial phase with a mean accuracy of 93.1%. Finally, using graph features, we reveal the increased significance of frontocentral, centroparietal, and temporal regions in memory encoding for subjects with pFC lesions and reduced information flow in the prefrontal, frontal and parietooccipital areas when compared to healthy control.
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Network curvature as a hallmark of brain structural connectivity
Although brain functionality is often remarkably robust to lesions and other insults, it may be fragile when these take place in specific locations. Previous attempts to quantify robustness and fragility sought to understand how the functional connectivity of brain networks is affected by structural changes, using either model-based predictions or empirical studies of the effects of lesions. We advance a geometric viewpoint relying on a notion of network curvature, the so-called Ollivier-Ricci curvature. This approach has been proposed to assess financial market robustness and to differentiate biological networks of cancer cells from healthy ones. Here, we apply curvature-based measures to brain structural networks to identify robust and fragile brain regions in healthy subjects. We show that curvature can also be used to track changes in brain connectivity related to age and autism spectrum disorder (ASD), and we obtain results that are in agreement with previous MRI studies.
more » « less- NSF-PAR ID:
- 10153763
- Publisher / Repository:
- Nature Publishing Group
- Date Published:
- Journal Name:
- Nature Communications
- Volume:
- 10
- Issue:
- 1
- ISSN:
- 2041-1723
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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