Carbon nanotubes (CNTs) exhibit a number of physicochemical properties that contribute to adverse biological outcomes. However, it is difficult to define the independent contribution of individual properties without purified materials. A library of highly purified single‐walled carbon nanotubes (SWCNTs) of different lengths is prepared from the same base material by density gradient ultracentrifugation, designated as short (318 nm), medium (789 nm), and long (1215 nm) SWCNTs. In vitro screening shows length‐dependent interleukin‐1β (IL‐1β) production, in order of long > medium > short. However, there are no differences in transforming growth factor‐β1 production in BEAS‐2B cells. Oropharyngeal aspiration shows that all the SWCNTs induce profibrogenic effects in mouse lung at 21 d postexposure, but there are no differences between tube lengths. In contrast, these SWCNTs demonstrate length‐dependent antibacterial effects on
- NSF-PAR ID:
- 10160747
- Date Published:
- Journal Name:
- International Journal of Molecular Sciences
- Volume:
- 20
- Issue:
- 19
- ISSN:
- 1422-0067
- Page Range / eLocation ID:
- 4802
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.3390/ijms20194802
