Abstract We present a method for measuring small, discrete features near the resolution limit of X‐ray computed tomography (CT) data volumes with the aim of providing consistent answers across instruments and data resolutions. The appearances of small features are impacted by the partial volume effect and blurring due to the data point‐spread function, and we call our approach the partial‐volume and blurring (PVB) method. Features are segmented to encompass their total attenuation signal, which is then converted to a volume, in turn allowing a subset of voxels to be used to measure shape and orientation. We demonstrate the method on a set of gold grains, scanned with two instruments at a range of resolutions and with various surrounding media. We recover volume accurately over a factor of 27 range in grain volume and factor of 5 range in data resolution, successfully characterizing particles as small as 5.4 voxels in true volume. Shape metrics are affected variably by resolution effects and are more reliable when based on image‐based caliper measurements than perimeter length or surface area. Orientations are reproducible when maximum or minimum axis lengths are sufficiently different from the intermediate axis. Calibration requires end‐member CT numbers for the materials of interest, which we obtained empirically; we describe a first‐principles calculation and discuss its challenges. The PVB method is accurate, reproducible, resolution invariant, and objective, all important improvements over any method based on global thresholds.
more »
« less
Resolution-invariant measurements of small objects in polychromatic CT data
Features such as particles, pores, or cracks are challenging to measure accurately in CT data when they are small relative to the data resolution, characterized as a point-spread function (PSF). These challenges are particularly acute when paired with segmentation, as the PSF distributes some of the signal from a voxel among neighboring ones; effectively dispersing some of the signal from a given object to a region outside of it. Any feature of interest with one or more dimensions on the order of the PSF will be impacted by this effect, and measurements based on global thresholds necessarily fail. Measurements of the same features should be consistent across different instruments and data resolutions. The PVB (partial volume and blurring) method successfully compensates by quantifying features that are small in all three dimensions based on their attenuation anomaly. By calibrating the CT number of the phase of interest (in this case, gold) it is possible to accurately measure particles down to <6 voxels in data acquired on two instruments, 14 years apart, despite severe artifacts. Altogether, the PVB method is accurate, reproducible, resolution-invariant, and objective; it is also notable for its favorable error structure. The principal challenge is the need for representative effective CT numbers, which reflect not only the features of interest themselves, but also the X-ray spectrum, the size, shape and composition of the enclosing sample, and processing details such as beam-hardening correction. Empirical calibration is the most effective approach.
more »
« less
- Award ID(s):
- 1762458
- PAR ID:
- 10164887
- Date Published:
- Journal Name:
- Developments in X-Ray Tomography XII
- Page Range / eLocation ID:
- 111130B
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract: Coded aperture X-ray computed tomography (CT) has the potential to revolutionize X-ray tomography systems in medical imaging and air and rail transit security - both areas of global importance. It allows either a reduced set of measurements in X-ray CT without degrada- tion in image reconstruction, or measure multiplexed X-rays to simplify the sensing geometry. Measurement reduction is of particular interest in medical imaging to reduce radiation, and airport security often imposes practical constraints leading to limited angle geometries. Coded aperture compressive X-ray CT places a coded aperture pattern in front of the X-ray source in order to obtain patterned projections onto a detector. Compressive sensing (CS) reconstruction algorithms are then used to recover the image. To date, the coded illumination patterns used in conventional CT systems have been random. This paper addresses the code optimization prob- lem for general tomography imaging based on the point spread function (PSF) of the system, which is used as a measure of the sensing matrix quality which connects to the restricted isom- etry property (RIP) and coherence of the sensing matrix. The methods presented are general, simple to use, and can be easily extended to other imaging systems. Simulations are presented where the peak signal to noise ratios (PSNR) of the reconstructed images using optimized coded apertures exhibit significant gain over those attained by random coded apertures. Additionally, results using real X-ray tomography projections are presented.more » « less
-
Abstract: Coded aperture X-ray computed tomography (CT) has the potential to revolutionize X-ray tomography systems in medical imaging and air and rail transit security - both areas of global importance. It allows either a reduced set of measurements in X-ray CT without degrada- tion in image reconstruction, or measure multiplexed X-rays to simplify the sensing geometry. Measurement reduction is of particular interest in medical imaging to reduce radiation, and airport security often imposes practical constraints leading to limited angle geometries. Coded aperture compressive X-ray CT places a coded aperture pattern in front of the X-ray source in order to obtain patterned projections onto a detector. Compressive sensing (CS) reconstruction algorithms are then used to recover the image. To date, the coded illumination patterns used in conventional CT systems have been random. This paper addresses the code optimization prob- lem for general tomography imaging based on the point spread function (PSF) of the system, which is used as a measure of the sensing matrix quality which connects to the restricted isom- etry property (RIP) and coherence of the sensing matrix. The methods presented are general, simple to use, and can be easily extended to other imaging systems. Simulations are presented where the peak signal to noise ratios (PSNR) of the reconstructed images using optimized coded apertures exhibit significant gain over those attained by random coded apertures. Additionally, results using real X-ray tomography projections are presented.more » « less
-
Micro-computed tomography (µCT) is a valuable tool for visualizing microstructures and damage in fiber-reinforced composites. However, the large sets of data generated by µCT present a barrier to extracting quantitative information. Deep learning models have shown promise for overcoming this barrier by enabling automated segmentation of features of interest from the images. However, robust validation methods have not yet been used to quantify the success rate of the models and the ability to extract accurate measurements from the segmented image. In this paper, we evaluate the detection rate for segmenting fibers in low-contrast CT images using a deep learning model with three different approaches for defining the reference (ground-truth) image. The feasibility of measuring sub-pixel feature dimensions from the µCT image, in certain cases where the µCT image intensity is dependent on the feature dimensions, is assessed and calibrated using a higher-resolution image from a polished cross-section of the test specimen in the same location as the µCT image.more » « less
-
Objective and Impact Statement . We propose an automated method of predicting Normal Pressure Hydrocephalus (NPH) from CT scans. A deep convolutional network segments regions of interest from the scans. These regions are then combined with MRI information to predict NPH. To our knowledge, this is the first method which automatically predicts NPH from CT scans and incorporates diffusion tractography information for prediction. Introduction . Due to their low cost and high versatility, CT scans are often used in NPH diagnosis. No well-defined and effective protocol currently exists for analysis of CT scans for NPH. Evans’ index, an approximation of the ventricle to brain volume using one 2D image slice, has been proposed but is not robust. The proposed approach is an effective way to quantify regions of interest and offers a computational method for predicting NPH. Methods . We propose a novel method to predict NPH by combining regions of interest segmented from CT scans with connectome data to compute features which capture the impact of enlarged ventricles by excluding fiber tracts passing through these regions. The segmentation and network features are used to train a model for NPH prediction. Results . Our method outperforms the current state-of-the-art by 9 precision points and 29 recall points. Our segmentation model outperforms the current state-of-the-art in segmenting the ventricle, gray-white matter, and subarachnoid space in CT scans. Conclusion . Our experimental results demonstrate that fast and accurate volumetric segmentation of CT brain scans can help improve the NPH diagnosis process, and network properties can increase NPH prediction accuracy.more » « less
An official website of the United States government

