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1. Analysis of the time-varying Cox model for the cause-specific hazard functions with missing causes

   https://doi.org/10.1007/s10985-020-09497-y  

   Heng, Fei; Sun, Yanqing; Hyun, Seunggeun; Gilbert, Peter B. (January 2020, Lifetime Data Analysis)

   This paper studies theCox model with time-varying coefficients for cause-specific hazard functions when the causes of failure are subject to missingness. Inverse probability weighted and augmented inverse probability weighted estimators are investigated. The latter is considered as a two-stage estimator by directly utilizing the inverse probability weighted estimator and through modeling available auxiliary variables to improve efficiency. The asymptotic properties of the two estimators are investigated. Hypothesis testing procedures are developed to test the null hypotheses that the covariate effects are zero and that the covariate effects are constant. We conduct simulation studies to examine the finite sample properties of the proposed estimation and hypothesis testing procedures under various settings of the auxiliary variables and the percentages of the failure causes that are missing. These simulation results demonstrate that the augmented inverse probability weighted estimators are more efficient than the inverse probability weighted estimators and that the proposed testing procedures have the expected satisfactory results in sizes and powers. The proposed methods are illustrated using the Mashi clinical trial data for investigating the effect of randomization to formula-feeding versus breastfeeding plus extended infant zidovudine prophylaxis on death due to mother-to-child HIV transmission in Botswana. 

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2. Statistical and Causal Robustness for Causal Null Hypothesis Tests

   Yang, Junhui; Bhattacharya, Rohit; Lee, Youjin; Westling, Ted (April 2024, arXiv)

   Prior work applying semiparametric theory to causal inference has primarily focused on deriving estimators that exhibit statistical robustness under a prespecified causal model that permits identification of a desired causal parameter. However, a fundamental challenge is correct specification of such a model, which usually involves making untestable assumptions. Evidence factors is an approach to combining hypothesis tests of a common causal null hypothesis under two or more candidate causal models. Under certain conditions, this yields a test that is valid if at least one of the underlying models is correct, which is a form of causal robustness. We propose a method of combining semiparametric theory with evidence factors. We develop a causal null hypothesis test based on joint asymptotic normality of asymptotically linear semiparametric estimators, where each estimator is based on a distinct identifying functional derived from each of candidate causal models. We show that this test provides both statistical and causal robustness in the sense that it is valid if at least one of the proposed causal models is correct, while also allowing for slower than parametric rates of convergence in estimating nuisance functions. We demonstrate the effectiveness of our method via simulations and applications to the Framingham Heart Study and Wisconsin Longitudinal Study. 

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3. Covariate-adjusted log-rank test: guaranteed efficiency gain and universal applicability

   https://doi.org/10.1093/biomet/asad045  

   Ye, Ting; Shao, Jun; Yi, Yanyao (July 2023, Biometrika)

   Summary Nonparametric covariate adjustment is considered for log-rank-type tests of the treatment effect with right-censored time-to-event data from clinical trials applying covariate-adaptive randomization. Our proposed covariate-adjusted log-rank test has a simple explicit formula and a guaranteed efficiency gain over the unadjusted test. We also show that our proposed test achieves universal applicability in the sense that the same formula of test can be universally applied to simple randomization and all commonly used covariate-adaptive randomization schemes such as the stratified permuted block and the Pocock–Simon minimization, which is not a property enjoyed by the unadjusted log-rank test. Our method is supported by novel asymptotic theory and empirical results for Type-I error and power of tests. 

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4. ASYMPTOTIC SIZE OF KLEIBERGEN’S LM AND CONDITIONAL LR TESTS FOR MOMENT CONDITION MODELS

   https://doi.org/10.1017/S0266466616000347  

   Andrews, Donald W.K.; Guggenberger, Patrik (October 2017, Econometric Theory)

   An influential paper by Kleibergen (2005, Econometrica 73, 1103–1123) introduces Lagrange multiplier (LM) and conditional likelihood ratio-like (CLR) tests for nonlinear moment condition models. These procedures aim to have good size performance even when the parameters are unidentified or poorly identified. However, the asymptotic size and similarity (in a uniform sense) of these procedures have not been determined in the literature. This paper does so. This paper shows that the LM test has correct asymptotic size and is asymptotically similar for a suitably chosen parameter space of null distributions. It shows that the CLR tests also have these properties when the dimension p of the unknown parameter θ equals 1. When p ≥ 2, however, the asymptotic size properties are found to depend on how the conditioning statistic, upon which the CLR tests depend, is weighted. Two weighting methods have been suggested in the literature. The paper shows that the CLR tests are guaranteed to have correct asymptotic size when p ≥ 2 when the weighting is based on an estimator of the variance of the sample moments, i.e., moment-variance weighting, combined with the Robin and Smith (2000, Econometric Theory 16, 151–175) rank statistic. The paper also determines a formula for the asymptotic size of the CLR test when the weighting is based on an estimator of the variance of the sample Jacobian. However, the results of the paper do not guarantee correct asymptotic size when p ≥ 2 with the Jacobian-variance weighting, combined with the Robin and Smith (2000, Econometric Theory 16, 151–175) rank statistic, because two key sample quantities are not necessarily asymptotically independent under some identification scenarios. Analogous results for confidence sets are provided. Even for the special case of a linear instrumental variable regression model with two or more right-hand side endogenous variables, the results of the paper are new to the literature. 

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5. Asymptotic normality of robust risk minimizers

   Minsker, Stanislav (January 2020, ArXivorg)

   null (Ed.)

   This paper investigates asymptotic properties of a class of algorithms that can be viewed as robust analogues of the classical empirical risk minimization. These strategies are based on replacing the usual empirical average by a robust proxy of the mean, such as the (version of) the median-of-means estimator. It is well known by now that the excess risk of resulting estimators often converges to 0 at optimal rates under much weaker assumptions than those required by their “classical” counterparts. However, much less is known about the asymptotic properties of the estimators themselves, for instance, whether robust analogues of the maximum likelihood estimators are asymptotically efficient. We make a step towards answering these questions and show that for a wide class of parametric problems, minimizers of the appropriately defined robust proxy of the risk converge to the minimizers of the true risk at the same rate, and often have the same asymptotic variance, as the estimators obtained by minimizing the usual empirical risk. Moreover, our results show that robust algorithms based on the so-called “min-max” type procedures in many cases provably outperform, is the asymptotic sense, algorithms based on direct risk minimization. 

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