skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: Defining the relationship between maternal care behavior and sensory development in Wistar rats: Auditory periphery development, eye opening and brain gene expression
Award ID(s):
1662970
PAR ID:
10189050
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
PLOS ONE
Volume:
15
Issue:
8
ISSN:
1932-6203
Page Range / eLocation ID:
e0237933
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. null (Ed.)
    Arabidopsis AINTEGUMENTA (ANT), an AP2 transcription factor, is known to control plant growth and floral organogenesis. In this study, our transcriptome analysis and in situ hybridization assays of maize embryonic leaves suggested that maize ANT1 (ZmANT1) regulates vascular development. To better understand ANT1 functions, we determined the binding motif of ZmANT1 and then showed that ZmANT1 binds the promoters of millet SCR1 , GNC , and AN3 , which are key regulators of Kranz anatomy, chloroplast development, and plant growth, respectively. We generated a mutant with a single-codon deletion and two frameshift mutants of the ANT1 ortholog in the C4 millet Setaria viridis by the CRISPR/Cas9 technique. The two frameshift mutants displayed reduced photosynthesis efficiency and growth rate, smaller leaves, and lower grain yields than wild-type (WT) plants. Moreover, their leaves sporadically exhibited distorted Kranz anatomy and vein spacing. Conducting transcriptomic analysis of developing leaves in the WT and the three mutants we identified differentially expressed genes (DEGs) in the two frameshift mutant lines and found many down-regulated DEGs enriched in photosynthesis, heme, tetrapyrrole binding, and antioxidant activity. In addition, we predicted many target genes of ZmANT1 and chose 13 of them to confirm binding of ZmANT1 to their promoters. Based on the above observations, we proposed a model for ANT1 regulation of cell proliferation and leaf growth, vascular and vein development, chloroplast development, and photosynthesis through its target genes. Our study revealed biological roles of ANT1 in several developmental processes beyond its known roles in plant growth and floral organogenesis. 
    more » « less
  2. null (Ed.)
    Connected vehicle (CV) application developers need a development platform to build, test, and debug real-world CV applications, such as safety, mobility, and environmental applications, in edge-centric cyber-physical system (CPS). The objective of this paper is to develop and evaluate a scalable and secure CV application development platform (CVDeP) that enables application developers to build, test, and debug CV applications in real-time while meeting the functional requirements of any CV applications. The efficacy of the CVDeP was evaluated using two types of CV applications (one safety and one mobility application) and they were validated through field experiments at the South Carolina Connected Vehicle Testbed (SC-CVT). The analyses show that the CVDeP satisfies the functional requirements in relation to latency and throughput of the selected CV applications while maintaining the scalability and security of the platform and applications. 
    more » « less