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1. Theranostic Potential of Adaptive Cold Atmospheric Plasma with Temozolomide to Checkmate Glioblastoma: An In Vitro Study

   https://doi.org/10.3390/cancers14133116  

   Soni, Vikas ; Adhikari, Manish ; Lin, Li ; Sherman, Jonathan H. ; Keidar, Michael ( July 2022 , Cancers)

   Cold atmospheric plasma (CAP) has been used for the treatment of various cancers. The anti-cancer properties of CAP are mainly due to the reactive species generated from it. Here, we analyze the efficacy of CAP in combination with temozolomide (TMZ) in two different human glioblastoma cell lines, T98G and A172, in vitro using various conditions. We also establish an optimized dose of the co-treatment to study potential sensitization in TMZ-resistant cells. The removal of cell culture media after CAP treatment did not affect the sensitivity of CAP to cancer cells. However, keeping the CAP-treated media for a shorter time helped in the slight proliferation of T98G cells, while keeping the same media for longer durations resulted in a decrease in its survivability. This could be a potential reason for the sensitization of the cells in combination treatment. Co-treatment effectively increased the lactate dehydrogenase (LDH) activity, indicating cytotoxicity. Furthermore, apoptosis and caspase-3 activity also significantly increased in both cell lines, implying the anticancer nature of the combination. The microscopic analysis of the cells post-treatment indicated nuclear fragmentation, and caspase activity demonstrated apoptosis. Therefore, a combination treatment of CAP and TMZ may be a potent therapeutic modality to treat glioblastoma. This could also indicate that a pre-treatment with CAP causes the cells to be more sensitive to chemotherapy treatment. 

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2. Cold Atmospheric Pressure Plasma Jet and Plasma Lamp Interaction with Plants: Electrostimulation, Reactive Oxygen and Nitrogen Species, and Side Effects

   https://doi.org/10.29328/journal.jpsp.1001110  

   Alexander G, Volkov ; Jewel S, Hairston ; Darayas, Patel ; Sergey, Sarkisov ( January 2023 , Journal of Plant Science and Phytopathology)

   Cold atmospheric pressure plasma (CAPP) treatment is a highly effective method of protecting seeds, plants, flowers, and trees from diseases and infection and significantly increasing crop yields. Here we found that cold atmospheric pressure He-plasma jet (CAPPJ) can also cause side effects and damage to plants if the plasma exposure time is too long. Reactive oxygen and nitrogen species (RONS), electromagnetic fields, and ultraviolet photons emitted by CAPPJ can cause both positive and negative effects on plants. CAPPJ can interact with biological tissue surfaces. The plasma lamp has no visible side effects on Aloe vera plants, cabbage, and tomatoes. A plasma lamp and a cold atmospheric pressure plasma He-jet cause strong electrical signaling in plants with a very high amplitude with frequencies equal to the frequency of plasma generation. The use of plasma lamps for electrostimulation of biological tissues can help to avoid side processes in biological tissues associated with the generation of RONS, UV photons, and direct interaction with cold plasma. CAPP technology can play an important role in agriculture, medicine, the food industry, chemistry, surface science, material science, and engineering applications without side effects if the plasma exposure is short enough. 

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3. Plasma Seeds: Cold Plasma Accelerates Phaseolus vulgaris Seeds Imbibition, Germination, and Speed of the Seedling Growth

   https://doi.org/10.1615/PlasmaMed.2020036438  

   Volkov, Alexander ; Hairston, Jewel ; Marshall, Jordan ; Bookal, Asya ; Dholichand, Andrew ; Pate, Darayas ( January 2021 , Plasma Medicine)

   null (Ed.)
4. Cold atmospheric pressure He-plasma jet and plasma ball interactions with the Venus flytrap: Electrophysiology and side effects

   https://doi.org/10.1016/j.bioelechem.2021.107833  

   Volkov, Alexander G. ( August 2021 , Bioelectrochemistry)

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5. Study of atmospheric pressure plasma jet parameters generated by DC voltage driven cold plasma source

   https://doi.org/10.1063/1.4986636  

   Wang, Xingxing ; Shashurin, Alexey ( August 2017 , Journal of Applied Physics)