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Title: Multi-functional Vacuum Ionization Source for MAI, LSI, and MALDI: Operational from AP for Comprehensive, Low-Cost Data-Mining in Mass Spectrometry
Unprecedented ionization processes developed into powerful methods have attributes highly desirable for MS and include high sensitivity, low cost, simplicity, ability to directly analyze biological and synthetic materials, potential for high throughput, automation, exceptional robustness, and wide applicability, especially in environments outside analytical laboratories. Initial matrix-assisted ionization (MAI) results showed different selectivity relative to ESI or MALDI providing information not readily obtained with current methodologies. Here, we demonstrate the first vacuum ionization source with multi-ionization capabilities on the same high-resolution API-mass spectrometer for a range of analytical problems with sensitivity in low fmol and detection limit in low amol ranges. The potential for achieving MS and MS/MS analysis speeds of ca. 4 seconds/sample in a simple low-cost fashion is demonstrated.
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68th Annual ASMS Conference on Mass Spectrometry and Allied Topics
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National Science Foundation
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