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Title: Synthesis of Oxazoline and Oxazole Derivatives by Hypervalent-Iodine-Mediated Oxidative Cycloaddition Reactions
Organohypervalent iodine reagents are widely used for the preparation of various oxazolines, oxazoles, isoxazolines, and isoxazoles. In the formation of these heterocyclic compounds, hypervalent iodine species can serve as the activating reagents for various substrates, as well as the heteroatom donor reagents. In recent research, both chemical and electrochemical approaches toward generation of hypervalent iodine species have been utilized. The in situ generated active species can react with appropriate substrates to give the corresponding heterocyclic products. In this short review, we summarize the hypervalent-iodine­-mediated preparation of oxazolines, oxazoles, isoxazolines, and isoxazoles starting from various substrates. 1 Introduction 2 Synthesis of Oxazolines 3 Synthesis of Oxazoles 4 Synthesis of Isoxazolines 5 Synthesis of Isoxazoles 6 Conclusion  more » « less
Award ID(s):
1759798
PAR ID:
10227136
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Synthesis
Volume:
52
Issue:
16
ISSN:
0039-7881
Page Range / eLocation ID:
2299 to 2310
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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