Surface-Radical Mobility Test by Self-Sorted Recombination: Symmetrical Product upon Recombination (SPR)
- Award ID(s):
- 1856765
- Publication Date:
- NSF-PAR ID:
- 10230570
- Journal Name:
- The Journal of Physical Chemistry B
- Volume:
- 125
- Issue:
- 16
- Page Range or eLocation-ID:
- 4212 to 4220
- ISSN:
- 1520-6106
- Sponsoring Org:
- National Science Foundation
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Schiffels, Stephan (Ed.)Movement of individuals between populations or demes is often restricted, especially between geographically isolated populations. The structured coalescent provides an elegant theoretical framework for describing how movement between populations shapes the genealogical history of sampled individuals and thereby structures genetic variation within and between populations. However, in the presence of recombination an individual may inherit different regions of their genome from different parents, resulting in a mosaic of genealogical histories across the genome, which can be represented by an Ancestral Recombination Graph (ARG). In this case, different genomic regions may have different ancestral histories and so different histories of movement between populations. Recombination therefore poses an additional challenge to phylogeographic methods that aim to reconstruct the movement of individuals from genealogies, although also a potential benefit in that different loci may contain additional information about movement. Here, we introduce the Structured Coalescent with Ancestral Recombination (SCAR) model, which builds on recent approximations to the structured coalescent by incorporating recombination into the ancestry of sampled individuals. The SCAR model allows us to infer how the migration history of sampled individuals varies across the genome from ARGs, and improves estimation of key population genetic parameters such as population sizes, recombination rates andmore »