More Like this

1. Characterization of Additively Manufactured Metals from ADDERE Printing

   Foster, J. ; Kumpaty, S. ; Coen, L. ; Perkins, A. ; Gengler, M. ; Woida, S. ( November 2022 , ASME International Mechanical Engineering Congress and Exposition)

   IMECE2022-88299 Midwest Engineered Systems Inc. has created a novel laser wire metal deposition process, ADDere manufacturing. ADDere has a much higher deposition rate than powder bed fusion, making it ideal for large components. In this project, the mechanical properties of ADDere printed materials were tested and compared to typical values found in ASM publications to show the quality of materials manufactured by the ADDere printing process. A detailed material analysis was performed on samples made from Ti-6Al-4V and 17-4 PH stainless steel. This work builds upon an earlier study of samples made from 17-4 PH that were produced using a single direction pattern. In this project, the 17-4 PH samples were printed in a cross hatched pattern, and testing results were compared to existing data from single direction samples of the previous research. The Ti-6Al-4V samples were created in two builds. One using the uni-directional method and the other with the crossed pattern. Testing specimens were removed from the samples using a water jet cutter and further machined into ASTM tensile bars and metallurgic mounts to perform a thorough material evaluation. The Ti-6Al-4V sample met the expected values in the ASM literature, and the cross hatched 17-4 PH exhibited a higher hardness and better microstructure than the single direction samples from the previous work. It was also observed that when the Ti64 samples were manufactured in the cross hatched pattern, the properties indicated slight improvement and more homogeneity than those printed in single layer direction. The obtained results indicate that ADDere’s printing process can produce highly refined materials that are customizable with their expected uses. This work showcases an excellent industry collaboration of an undergraduate research experience. 

   more » « less
2. Online control of the familywise error rate

   https://doi.org/10.1177/0962280220983381  

   Tian, Jinjin ; Ramdas, Aaditya ( April 2021 , Statistical Methods in Medical Research)

   null (Ed.)

   Biological research often involves testing a growing number of null hypotheses as new data are accumulated over time. We study the problem of online control of the familywise error rate, that is testing an a priori unbounded sequence of hypotheses ( p-values) one by one over time without knowing the future, such that with high probability there are no false discoveries in the entire sequence. This paper unifies algorithmic concepts developed for offline (single batch) familywise error rate control and online false discovery rate control to develop novel online familywise error rate control methods. Though many offline familywise error rate methods (e.g., Bonferroni, fallback procedures and Sidak’s method) can trivially be extended to the online setting, our main contribution is the design of new, powerful, adaptive online algorithms that control the familywise error rate when the p-values are independent or locally dependent in time. Our numerical experiments demonstrate substantial gains in power, that are also formally proved in an idealized Gaussian sequence model. A promising application to the International Mouse Phenotyping Consortium is described. 

   more » « less
3. Algorithmic Pulsar Timing

   https://doi.org/10.3847/1538-3881/ac403e  

   Phillips, Camryn ; Ransom, Scott ( January 2022 , The Astronomical Journal)

   Abstract Pulsar timing is a process of iteratively fitting pulse arrival times to constrain the spindown, astrometric, and possibly binary parameters of a pulsar, by enforcing integer numbers of pulsar rotations between the arrival times. Phase connection is the process of unambiguously determining those rotation numbers between the times of arrival while determining a pulsar timing solution. Pulsar timing currently requires a manual process of step-by-step phase connection performed by individuals. In an effort to quantify and streamline this process, we created the Algorithmic Pulsar Timer (APT), an algorithm that can accurately phase connect and time isolate pulsars. Using the statistical F-test and knowledge of parameter uncertainties and covariances, the algorithm decides what new data to include in a fit, when to add additional timing parameters, and which model to attempt in subsequent iterations. Using these tools, the algorithm can phase-connect timing data that previously required substantial manual effort. We tested the algorithm on 100 simulated systems, with a 99% success rate. APT combines statistical tests and techniques with a logical decision-making process, very similar to the manual one used by pulsar astronomers for decades, and some computational brute force, to automate the often tricky process of isolated pulsar phase connection, setting the foundation for automated fitting of binary pulsar systems. 

   more » « less
4. Speckle Space–Time Covariance in High-contrast Imaging

   https://doi.org/10.3847/1538-3881/aca761  

   Lewis, Briley ; Fitzgerald, Michael P. ; Dodkins, Rupert H. ; Davis, Kristina K. ; Lin, Jonathan ( January 2023 , The Astronomical Journal)

   We introduce a new framework for point-spread function subtraction based on the spatiotemporal variation of speckle noise in high-contrast imaging data where the sampling timescale is faster than the speckle evolution timescale. One way that space–time covariance arises in the pupil is as atmospheric layers translate across the telescope aperture and create small, time-varying perturbations in the phase of the incoming wavefront. The propagation of this field to the focal plane preserves some of that space–time covariance. To utilize this covariance, our new approach uses a Karhunen–Loève transform on an image sequence, as opposed to a set of single reference images as in previous applications of Karhunen–Loève Image Processing (KLIP) for high-contrast imaging. With the recent development of photon-counting detectors, such as microwave kinetic inductance detectors, this technique now has the potential to improve contrast when used as a post-processing step. Preliminary testing on simulated data shows this technique can improve contrast by at least 10%–20% from the original image, with significant potential for further improvement. For certain choices of parameters, this algorithm may provide larger contrast gains than spatial-only KLIP.

    

   more » « less
5. Early photon optical tomography signal-to-noise ratio improved by almost two orders-of-magnitude by running in the “deadtime” regime

   Sinha, L. ; Zhou, W. ; Brankov, J.G. ; Tichauer, K.M ( January 2017 , World Molecular Imaging Congress 2017)

   Optical projection tomography (OPT) is a powerful imaging modality for attaining high resolution absorption and fluorescence imaging in tissue samples and embryos with a diameter of roughly 1 mm. Moving past this 1 mm limit, scattered light becomes the dominant fraction detected, adding significant “blur” to OPT. Time-domain OPT has been used to select out early-arriving photons that have taken a more direct route through the tissue to reduce detection of scattered photons in these larger samples, which are the cause of image domain blur1. In addition, it was recently demonstrated by our group that detection of scattered photons could be further depressed by running in a “deadtime” regime where laser repetition rates are selected such that the deadtime incurred by early-arriving photons acts as a shutter to later-arriving scattered photons2. By running in this deadtime regime, far greater early photon count rates are achievable than with standard early photon OPT. In this work, another advantage of this enhanced early photon collection approach is demonstrated: specifically, a significant improvement in signal-to-noise ratio. In single photon counting detectors, the main source of noise is “afterpulsing,” which is essentially leftover charge from a detected photon that spuriously results in a second photon count. When the arrival of the photons are time-stamped by the time correlated single photon counting (TCSPC) module , the rate constant governing afterpusling is slow compared to the time-scale of the light pulse detected so it is observed as a background signal with very little time-correlation. This signal is present in all time-gates and so adds noise to the detection of early photons. However, since the afterpusling signal is proportional to the total rate of photon detection, our enhanced early photon approach is uniquely able to have increased early photon counts with no appreciable increase in the afterpulsing since overall count-rate does not change. This is because as the rate of early photon detection goes up, the rate of late-photon detection reduces commensurately, yielding no net change in the overall rate of photons detected. This hypothesis was tested on a 4 mm diameter tissue-mimicking phantom (μa = 0.02 mm-1, μs’ = 1 mm-1) by ranging the power of a 10 MHz pulse 780-nm laser with pulse spread of < 100 fs (Calmar, USA) and an avalanche photodiode (MPD, Picoquant, Germany) and TCSPC module (HydraHarp, Picoquant, Germany) for light detection. Details of the results are in Fig. 1a, but of note is that we observed more than a 60-times improvement in SNR compared to conventional early photon detection that would have taken 1000-times longer to achieve the same early photon count. A demonstration of the type of resolution possible is in Fig 1b with an image of a 4-mm-thick human breast cancer biopsy where tumor spiculations of less than 100 μm diameter are observable. 1Fieramonti, L. et al. PloS one (2012). 2Sinha, L., et al. Optics letters (2016). 

   more » « less