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  • Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical
Title: Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical
Product analysis from the iron Fenton oxidation of 2′-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2′-deoxyguanosine and spiroiminodihyantoin consistent with CO 3 ˙ − . Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.  more » « less
Award ID(s):
1808475
PAR ID:
10276291
Author(s) / Creator(s):
;
Date Published:
Journal Name:
Chemical Communications
Volume:
56
Issue:
68
ISSN:
1359-7345
Page Range / eLocation ID:
9779 to 9782
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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