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1. Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response

   https://doi.org/10.1039/d0lc01283a  

   Walther, Brandon K. ; Rajeeva Pandian, Navaneeth Krishna ; Gold, Karli A. ; Kiliç, Ecem S. ; Sama, Vineeth ; Gu, Jianhua ; Gaharwar, Akhilesh K. ; Guiseppi-Elie, Anthony ; Cooke, John P. ; Jain, Abhishek ( May 2021 , Lab on a Chip)

   Endothelial mechanobiology is a key consideration in the progression of vascular dysfunction, including atherosclerosis. However mechanistic connections between the clinically associated physical stimuli, vessel stiffness and shear stress, and how they interact to modulate plaque progression remain incompletely characterized. Vessel-chip systems are excellent candidates for modeling vascular mechanobiology as they may be engineered from the ground up, guided by the mechanical parameters present in human arteries and veins, to recapitulate key features of the vasculature. Here, we report extensive validation of a vessel-chip model of endothelial yes-associated protein (YAP) mechanobiology, a protein sensitive to both matrix stiffness and shearing forces and, importantly, implicated in atherosclerotic progression. Our model captures the established endothelial mechanoresponse, with endothelial alignment, elongation, reduction of adhesion molecules, and YAP cytoplasmic retention under high laminar shear. Conversely, we observed disturbed morphology, inflammation, and nuclear partitioning under low, high, and high oscillatory shear. Examining targets of YAP transcriptional co-activation, connective tissue growth factor (CTGF) is strongly downregulated by high laminar shear, whereas it is strongly upregulated by low shear or oscillatory flow. Ankyrin repeat domain 1 (ANKRD1) is only upregulated by high oscillatory shear. Verteporfin inhibition of YAP reduced the expression of CTGF but did not affect ANKRD1. Lastly, substrate stiffness modulated the endothelial shear mechanoresponse. Under high shear, softer substrates showed the lowest nuclear localization of YAP whereas stiffer substrates increased nuclear localization. Low shear strongly increased nuclear localization of YAP across stiffnesses. Together, we have validated a model of endothelial mechanobiology and describe a clinically relevant biological connection between matrix stiffness, shear stress, and endothelial activation via YAP mechanobiology. 

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2. THz Channel Characterization of Chip-to-Chip Communication in Desktop Size Metal Enclosure

   https://doi.org/10.1109/TAP.2019.2934908  

   Fu, Jinbang ; Juyal, Prateek ; Zajic, Alenka ( December 2019 , IEEE Transactions on Antennas and Propagation)
3. 25.8 A Near- Threshold-Voltage Network-on-Chip with a Metastability Error Detection and Correction Technique for Supporting a Quad-Voltage/Frequency-Domain Ultra-Low-Power System-on-a-Chip

   https://doi.org/10.1109/ISSCC19947.2020.9063126  

   Lin, Chuxiong ; He, Weifeng ; Sun, Yanan ; Pei, Bingxi ; Mao, Zhigang ; Seok, Mingoo ( February 2020 , IEEE International Solid-State Circuits Conference (ISSCC))

   Emerging embedded systems, such as autonomous robots/vehicles, demand a new system-on-a-chip (SoC) that is ultra-low power (mW or even sub-mW level) but highly robust. Such an SoC typically integrates heterogeneous building blocks for supporting a range of features, each ideally operating in an independent voltage and frequency (V/F) domain [1]. In such an architecture, a network-on-chip (NoC) has played a key role to enable high-speed and energy-efficient networking. However, it is increasingly challenging to meet a robustness target since each V/F domain uses a significantly different voltage, e.g., from nominal 1V to near-threshold voltage (NTV), and clock frequency, e.g., from hundreds of MHz to sub-MHz. Furthermore, any two clocks may have uncertain and time-varying phase and frequency relationships. These properties significantly worsen robustness, particularly metastability, in an NoC. 

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4. Innovative propagation mechanism for inter-chip and intra-chip communication

   https://doi.org/10.1109/WAMICON.2015.7120367  

   Liu, Yuqiao ; Pano, Vasil ; Patron, Damiano ; Dandekar, Kapil ; Taskin, Baris ( April 2015 , 2015 IEEE 16th Annual Wireless and Microwave Technology Conference, WAMICON 2015)

   null (Ed.)
5. Chip-to-Chip Switched Beam 60 GHz Circular Patch Planar Antenna Array and Pattern Considerations

   https://doi.org/10.1109/TAP.2018.2803135  

   Baniya, Prabhat ; Bisognin, Aimeric ; Melde, Kathleen L. ; Luxey, Cyril ( April 2018 , IEEE Transactions on Antennas and Propagation)