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1. Design Approaches and Electromechanical Modeling of Conformable Piezoelectric‐Based Ultrasound Systems

   https://doi.org/10.1002/adsr.202300175  

   Amiri, Nikta; Shah, Aastha; Bhayadia, Amit_Kumar; Yu, Chia‐Chen; Karami, M_Amin; Dagdeviren, Canan (May 2024, Advanced Sensor Research)

   Abstract Painless, needleless delivery of drugs through the skin can be realized through aphenomenon called sonophoresis by applying an ultrasound field to the biological tissue. Development of wearable embodiments of such systems demands comprehensive characterization of both the physical mechanism of sonophoresisas well as wearability parameters. Here, we present a framework for analyzing disk‐type piezoelectric transducers in a polymeric substrate to create acoustic cavitation in a fluid coupling medium for sonophoresis applications. The device design and operating parameters such as the working frequency, applied voltage range, acoustic pressure distribution, and transducer spacing were determine dusing a finite element methods (FEM),and verified with experimental measurements. The influence of the surrounding water and tank reflections on the acoustic pressure field, and the interaction between the elements in the array structure were also studied.Finally, the impact of skin and the substrate geometry on the acoustic pressure fields was characterized to simulate the invivo use‐case of the system. These analytical models can be used to guide critical parameters for device design such as the separation distance of the piezoelectric transducer from the skin boundary. We envision that this tool boxwill support rapid design iteration for realization of wearable ultrasound systems. 

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2. Decoding of Facial Strains via Conformable Piezoelectric Interfaces

   Sun, T.; Tasnim, F.; McIntosh, R. T.; Amiri, N.; Solav, D.; Anbarani, M. T.; Sadat, S.; Zhang, L.; Gu, Y.; Karami, M. A.; et al (October 2020, Nature biomedical engineering)

   null (Ed.)

   Devices that facilitate nonverbal communication typically require high computational loads or have rigid and bulky form factors that are unsuitable for use on the face or on other curvilinear body surfaces. Here, we report the design and pilot testing of an integrated system for decoding facial strains and for predicting facial kinematics. The system consists of mass-manufacturable, conformable piezoelectric thin films for strain mapping; multiphysics modelling for analysing the nonlinear mechanical interactions between the conformable device and the epidermis; and three-dimensional digital image correlation for reconstructing soft-tissue surfaces under dynamic deformations as well as for informing device design and placement. In healthy individuals and in patients with amyotrophic lateral sclerosis, we show that the piezoelectric thin films, coupled with algorithms for the real-time detection and classification of distinct skin-deformation signatures, enable the reliable decoding of facial movements. The integrated system could be adapted for use in clinical settings as a nonverbal communication technology or for use in the monitoring of neuromuscular conditions. 

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3. Oligodendrocyte Tethering Effect on Hyperelastic 3D Response of Injured Axons in Brain White Matter

   https://doi.org/10.1115/IMECE2021-73376  

   Agarwal, Mohit; Pasupathy, Parameshwaran; De Simone, Robert; Pelegri, Assimina A. (November 2021, ASME International Mechanical Engineering Congress and Exposition (IMECE))

   Abstract Numerical simulations using non-linear hyper-elastic material models to describe interactions between brain white matter (axons and extra cellular matrix (ECM)) have enabled high-fidelity characterization of stress-strain response. In this paper, a novel finite element model (FEM) has been developed to study mechanical response of axons embedded in ECM when subjected to tensile loads under purely non-affine kinematic boundary conditions. FEM leveraging Ogden hyper-elastic material model is deployed to understand impact of parametrically varying oligodendrocyte-axon tethering and analyze influence of aging material characteristics on stress propagation. In proposed FEM, oligodendrocyte connections to axons are represented via spring-dashpot model, such tethering technique facilitates contact definition at various locations, parameterize connection points and vary stiffness of connection hubs. Two FE submodels are discussed: 1) multiple oligodendrocytes arbitrarily tethered to the nearest axons, and 2) single oligodendrocyte tethered to all axons at various locations. Root mean square deviation (RMSD) were computed between stress-strain plots to depict trends in mechanical response. Axonal stiffness was found to rise with increasing tethering, indicating role of oligodendrocytes in stress redistribution. Finally, stress state results for aging axon material, with varying stiffnesses and number of connections in FEM ensemble have also been discussed to demonstrate gradual softening of tissues. 

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4. Design and Computational Modeling of Fabric Soft Pneumatic Actuators for Wearable Assistive Devices

   https://doi.org/10.1038/s41598-020-65003-2  

   Nguyen, Pham Huy; Zhang, Wenlong (June 2020, Scientific Reports)

   Abstract Assistive wearable soft robotic systems have recently made a surge in the field of biomedical robotics, as soft materials allow safe and transparent interactions between the users and devices. A recent interest in the field of soft pneumatic actuators (SPAs) has been the introduction of a new class of actuators called fabric soft pneumatic actuators (FSPAs). These actuators exploit the unique capabilities of different woven and knit textiles, including zero initial stiffness, full collapsibility, high power-to-weight ratio, puncture resistant, and high stretchability. By using 2D manufacturing methods we are able to create actuators that can extend, contract, twist, bend, and perform a combination of these motions in 3D space. This paper presents a comprehensive simulation and design tool for various types of FSPAs using finite element method (FEM) models. The FEM models are developed and experimentally validated, in order to capture the complex non-linear behavior of individual actuators optimized for free displacement and blocked force, applicable for wearable assistive tasks. 

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5. Application of Digital Image Correlation (DIC) to the Measurement of Strain Concentration of a PVA Dual-Crosslink Hydrogel Under Large Deformation

   https://doi.org/10.1007/s11340-019-00520-4  

   Liu, M.; Guo, J.; Hui, C.-Y.; Zehnder, A. T. (January 2019, Experimental Mechanics)

   Hydrogels are a class of soft, highly deformable materials formed by swelling a network of polymer chains in water. With mechanical properties that mimic biological materials, hydrogels are often proposed for load bearing biomedical or other applications in which their deformation and failure properties will be important. To study the failure of such materials a means for the measurement of deformation fields beyond simple uniaxial tension tests is required. As a non-contact, full-field deformation measurement method, Digital Image Correlation (DIC) is a good candidate for such studies. The application of DIC to hydrogels is studied here with the goal of establishing the accuracy of DIC when applied to hydrogels in the presence of large strains and large strain gradients. Experimental details such as how to form a durable speckle pattern on a material that is 90% water are discussed. DIC is used to measure the strain field in tension loaded samples containing a central hole, a circular edge notch and a sharp crack. Using a nonlinear, large deformation constitutive model, these experiments are modeled using the finite element method (FEM). Excellent agreement between FEM and DIC results for all three geometries shows that the DIC measurements are accurate up to strains of over 10, even in the presence of very high strain gradients near a crack tip. The method is then applied to verify a theoretical prediction that the deformation field in a cracked sample under relaxation loading, i.e. constant applied boundary displacement, is stationary in time even as the stress relaxes by a factor of three. 

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