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Title: Modular Design of Supramolecular Ionic Peptides with Cell‐Selective Membrane Activity
Abstract The rational design of materials with cell‐selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme‐mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β‐sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self‐assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emerging membrane activity for a range of disease targeted molecular imaging and therapy applications.  more » « less
Award ID(s):
1824614
PAR ID:
10308329
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
ChemBioChem
Volume:
22
Issue:
22
ISSN:
1439-4227
Format(s):
Medium: X Size: p. 3164-3168
Size(s):
p. 3164-3168
Sponsoring Org:
National Science Foundation
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