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   https://doi.org/10.1051/mmnp/2019043  

   Cho, Heyrim ; Levy, Doron ( January 2020 , Mathematical Modelling of Natural Phenomena)

   Hubert, Florence (Ed.)

   Cell competition is recognized to be instrumental to the dynamics and structure of the tumor-host interface in invasive cancers. In mild competition scenarios, the healthy tissue and cancer cells can coexist. When the competition is aggressive, competitive cells, the so called super-competitors, expand by killing other cells. Novel chemotherapy drugs and molecularly targeted drugs are commonly administered as part of cancer therapy. Both types of drugs are susceptible to various mechanisms of drug resistance, obstructing or preventing a successful outcome. In this paper, we develop a cancer growth model that accounts for the competition between cancer cells and healthy cells.more »The model incorporates resistance to both chemotherapy and targeted drugs. In both cases, the level of drug resistance is assumed to be a continuous variable ranging from fully-sensitive to fully-resistant. Using our model we demonstrate that when the competition is moderate, therapies using both drugs are more effective compared with single drug therapies. However, when cancer cells are highly competitive, targeted drugs become more effective. The results of the study stress the importance of adjusting the therapy to the pre-treatment resistance levels. We conclude with a study of the spatiotemporal propagation of drug resistance in a competitive setting, verifying that the same conclusions hold in the spatially heterogeneous case.« less
2. CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells: CRISPR/Cas9-Mediated Fluorescent Tagging of Proteins in Pluripotent Stem Cells

   https://doi.org/10.1002/cphg.52  

   Sharma, Arun ; Toepfer, Christopher N. ; Ward, Tarsha ; Wasson, Lauren ; Agarwal, Radhika ; Conner, David A. ; Hu, Johnny H. ; Seidman, Christine E. ( January 2018 , Current Protocols in Human Genetics)
3. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells

   https://doi.org/10.1016/j.jbc.2021.100386  

   Mischler, Adam ; Karakis, Victoria ; Mahinthakumar, Jessica ; Carberry, Celeste K. ; San Miguel, Adriana ; Rager, Julia E. ; Fry, Rebecca C. ; Rao, Balaji M. ( January 2021 , Journal of Biological Chemistry)
4. The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics: PaParE toxin partially protects cells from antibiotic toxicity

   https://doi.org/10.1111/mmi.14165  

   Muthuramalingam, Meenakumari ; White, John C. ; Murphy, Tamiko ; Ames, Jessica R. ; Bourne, Christina R. ( February 2019 , Molecular Microbiology)
5. Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption

   https://doi.org/10.1167/tvst.9.8.23  

   Ameri, Hossein ; Murat, Christopher ; Arbabi, Amirmohsen ; Jiang, Wei ; Janga, Srikanth R. ; Qin, Peter Zhifeng ; Hamm-Alvarez, Sarah F. ( July 2020 , Translational Vision Science & Technology)