Neural signal recording and optical stimulation using implantable devices have become a ubiquitous method to treat brain disorders, yet there lie some shortcomings, such as size, weight, and functionalities of the implants. This work presents a commercial off-the-shelf (COTS) component-based miniaturized wireless optogenetic headstage with simultaneous optical stimulation and electrophysiological recording for freely moving rats. The system includes a battery-based neural stimulator consisting of a low-dropout (LDO) regulator, an oscillator, and a μ LED. The electrophysiological signal recording system includes an intracortical neural probe implemented on a shape memory polymer (SMP) substrate, an array of neural amplifiers with an integrated analog-to-digital converter (ADC), a transceiver IC, and a ceramic antenna. A digital sub-1-GHz transceiver integrated with a low-power microcontroller (MCU) is used to transmit the acquired neural data to a remote receiver unit, followed by offline spike detection and sorting in LabVIEW. The front-end recording amplifiers provide a gain of 45.7 dB with the input-referred noise of 2.4μVrms . The integrated multiplexer (MUX) with the ADC allows sampling of the amplified voltage at a configurable sampling rate of 160–480 kSamples/s. The total power consumption of the stimulation and the recording system is 23 mW. The dimension of the headstage device is 13.5×21.3 mm, weighing 4 g without the battery. The system is experimentally validated in an in vivo setting by placing the headstage on the head of a male rat and recording the neural signals from the ventral tegmental area (VTA) of the brain. This integrative neural signal recording and spike sorting approach would be useful for the development of a closed-loop neuromodulation system.
more »
« less
Design, Simulation and Comparison of two 15mm × 15mm UWB Antennas with Modified Ground Patch for High Data-rate Wireless Electrophysiological Recording Application
For the diagnosis and treatment of various chronic neurological diseases such as Epilepsy, Seizure and, chronic pain, a long-term electrophysiological recording and stimulation are required for the patients. This type of study can be done through implantable neuromodulation devices. One of the key challenges in designing such implantable medical devices is the size restriction. Even the antennas transmitting the recorded signals must be small, miniaturized, and light-weight in order for the small animals used in the clinical studies to carry it easily. In this paper, two 15mm×15mm antennas are designed which have ultra-wide bandwidths making them suitable for the high data rate electrophysiological recording applications. The proposed antennas are bidirectional and small in size making them suitable to be added to the headstage based electrophysiological recording devices. Both antennas have a similar radiating patches with each ground patch modified by creating two different slots. A comparison of the proposed antenna is presented in the paper where both antennas operate within 4.7 GHz to 8.3 GHz and having average gain above 4.35 dBi. Though the proposed antennas are 40% smaller in size, they have 6% higher gain compared to the state of the arts.
more »
« less
- Award ID(s):
- 1943990
- NSF-PAR ID:
- 10314082
- Date Published:
- Journal Name:
- 2021 IEEE Texas Symposium on Wireless and Microwave Circuits and Systems (WMCS)
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Diagnosis of neural diseases can be performed using microsystems that record neural signals collected simultaneously after neural simulations. Headstage and homecage-based recording systems can be implanted on small freely-moving animals to test such system which requires miniaturized, lightweight, and high gain antennas in order for the small animals to carry them easily while also decreasing loss during data transmission. This paper proposes a 15×15 mm2 slot antenna with a 50 Ω microstrip excitation line. The slot antenna is created by the addition of slots in the ground plane which is a common miniaturization method as it results in ultrawideband operating frequency. A lumped component-based model along with a 3D EM model of the modified SMA connector used for the measurement and headstage model is also developed to observe the effect on the antenna performance. The antenna achieved an operating frequency of 4.25 - 9.4 GHz and a bidirectional radiation pattern with gain ranging from 2.24 to 4.35 dBi. The proposed antenna is also circularly polarized and achieves 80.6% - 90.8% radiation efficiency over the operating BW. It can transmit a maximum of 20 dBm of power over the operating frequency without exceeding the FCC-imposed SAR limit. Based on the performance, the antenna is suitable for headstage and homecage-based neural signal recording systems with IR-UWB transmitter for high data rate transmission.more » « less
-
null (Ed.)This paper presents the design of a dual-band printed planar antenna for deep space CubeSat communications. The antenna system will be used with a radio for duplex operation in a CubeSat, which can be used for a lunar mission or any deep space mission. While a high-gain CubeSat planar antenna/array is always desired for a deep space mission, high-performance ground stations are also required for robust communication links. For such a mission, the X-band is the appropriate frequency for the downlink communication, which is very challenging in the case of deep space communication compared to the uplink communication. At this frequency, the antenna size can have small enough dimension to form an array to obtain high-gain directional radiations for the successful communication, including telemetry and data download. NASA’s Deep Space Network (DSN) has the largest and most sensitive 70 meterdiameter antenna that can be considered for this type of mission for reliability. DSN has uplink and downlink frequency of operations in 7.1-GHz and 8.4-GHz bands, respectively, which are separated by approximately 1.3 GHz. A straight forward approach is to use two antennas to cover uplink and downlink frequencies. However, CubeSats have huge space constraints to accommodate science instruments and other subsystems and commonly utilize outside faces for solar cells. Therefore, in this paper, we have proposed a planar directional circularly polarized antenna with a single feed that operates at both uplink and downlink DSN frequencies. Simulated 3-dB axial ratio bandwidth of 165 MHz, from 7064 MHz to 7229 MHz for uplink, and that of 183 MHz, from 8325 MHz to 8508 MHz for downlink, are achieved. Also, a wide impedance bandwidth of 23.86% (VSWR < 2) is obtained. From this single probe-fed stacked patch antenna, peak RHCP gain of 9.24 dBic can be achieved.more » « less
-
This paper presents a wideband circularly polarized antenna for small satellites to be used with NASA Near- Earth Networks (NEN). This single-fed stacked antenna utilizes the electromagnetic coupling concept and is usable with a duplex transceiver. The circularly-polarized antenna employs hybrid perturbations on stacked patches and covers NASA NEN’s both uplink and downlink frequencies, thus replacing the conventional requirement of two separate antennas. It provides a notable wide axial ratio (AR) < 3 dB bandwidth of 1.16 GHz from 7.02 GHz to 8.18 GHz (15.3%). The optimized patch dimensions provide 34.6% VSWR ~ 2 bandwidth from 6,525 MHz to 9,253 MHz. The overall antenna size is 17 mm × 17 mm × 6.6 mm, and has a peak gain of 7.9 dBi. This proposed antenna will overcome solar cell space constraint on smallsat’s outer wall by saving at least 50% area required by the conventional two-antenna method.more » « less
-
Introduction:Current brain-computer interfaces (BCIs) primarily rely on visual feedback. However, visual feedback may not be sufficient for applications such as movement restoration, where somatosensory feedback plays a crucial role. For electrocorticography (ECoG)-based BCIs, somatosensory feedback can be elicited by cortical surface electro-stimulation [1]. However, simultaneous cortical stimulation and recording is challenging due to stimulation artifacts. Depending on the orientation of stimulating electrodes, their distance to the recording site, and the stimulation intensity, these artifacts may overwhelm the neural signals of interest and saturate the recording bioamplifiers, making it impossible to recover the underlying information [2]. To understand how these factors affect artifact propagation, we performed a preliminary characterization of ECoG signals during cortical stimulation.Materials/Methods/ResultsECoG electrodes were implanted in a 39-year old epilepsy patient as shown in Fig. 1. Pairs of adjacent electrodes were stimulated as a part of language cortical mapping. For each stimulating pair, a charge-balanced biphasic square pulse train of current at 50 Hz was delivered for five seconds at 2, 4, 6, 8 and 10 mA. ECoG signals were recorded at 512 Hz. The signals were then high-pass filtered (≥1.5 Hz, zero phase), and the 5-second stimulation epochs were segmented. Within each epoch, artifact-induced peaks were detected for each electrode, except the stimulating pair, where signals were clipped due to amplifier saturation. These peaks were phase-locked across electrodes and were 20 ms apart, thus matching the pulse train frequency. The response was characterized by calculating the median peak within the 5-second epochs. Fig. 1 shows a representative response of the right temporal grid (RTG), with the stimulation channel at RTG electrodes 14 and 15. It also shows a hypothetical amplifier saturation contour of an implantable, bi-directional, ECoG-based BCI prototype [2], assuming the supply voltage of 2.2 V and a gain of 66 dB. Finally, we quantify the worstcase scenario by calculating the largest distance between the saturation contour and the midpoint of each stimulating channel.Discussion:Our results indicate that artifact propagation follows a dipole potential distribution with the extent of the saturation region (the interior of the white contour) proportional to the stimulation amplitude. In general, the artifacts propagated farthest when a 10 mA current was applied with the saturation regions extending from 17 to 32 mm away from the midpoint of the dipole. Consistent with the electric dipole model, this maximum spread happened along the direction of the dipole moment. An exception occurred at stimulation channel RTG11-16, for which an additional saturation contour emerged away from the dipole contour (not shown), extending the saturation region to 41 mm. Also, the worst-case scenario was observed at 6 mA stimulation amplitude. This departure could be a sign of a nonlinear, switch-like behavior, wherein additional conduction pathways could become engaged in response to sufficiently high stimulation.Significance:While ECoG stimulation is routinely performed in the clinical setting, quantitative studies of the resulting signals are lacking. Our preliminary study demonstrates that stimulation artifacts largely obey dipole distributions, suggesting that the dipole model could be used to predict artifact propagation. Further studies are necessary to ascertain whether these results hold across other subjects and combinations of stimulation/recording grids. Once completed, these studies will reveal practical design constraints for future implantable bi-directional ECoG-based BCIs. These include parameters such as the distances between and relative orientations of the stimulating and recording electrodes, the choice of the stimulating electrodes, the optimal placement of the reference electrode, and the maximum stimulation amplitude. These findings would also have important implications for the design of custom, low-power bioamplifiers for implantable bi-directional ECoG-based BCIs.References:[1] Hiremath, S. V., et al. "Human perception of electrical stimulation on the surface of somatosensory cortex." PloS one 12.5 (2017): e0176020.[2] Rouse, A. G., et al. "A chronic generalized bi-directional brain-machine interface." Journal of Neural Engineering 8.3 (2011): 036018more » « less
- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Conference Paper:
- https://doi.org/10.1109/WMCS52222.2021.9493275
