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   https://doi.org/10.1021/acs.joc.9b01908  

   O’Dea, Connor; Ugarte Trejo, Omar; Arras, Janet; Ehnbom, Andreas; Bhuvanesh, Nattamai; Stollenz, Michael (October 2019, The Journal of Organic Chemistry)
2. Template-Free Synthesis of a Macrocyclic Bis(pyridine-dienamine) Proligand and Metal Complexes of Its Bis(pyridine-diimine) and Bis(pyridine-dienamido) Forms

   https://doi.org/10.1021/acs.inorgchem.9b02539  

   Reinhart, Erik D.; Jordan, Richard F. (November 2019, Inorganic Chemistry)
3. Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents

   https://doi.org/10.1039/d0ra06148d  

   Das, Prasanta; Boone, Sarah; Mitra, Dipanwita; Turner, Lindsay; Tandon, Ritesh; Raucher, Drazen; Hamme, Ashton T. (August 2020, RSC Advances)

   null (Ed.)

   Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cytotoxicity against glioblastomas (GBM6) and triple negative breast cancer (MDA MB 231). Interestingly, compounds 4d and 4n showed significant activity against HCMV (IC 50 ∼ 10 μM), while 4l and 5f revealed the highest cytotoxicity with IC 50 = 36 to 80 μM. The synthetic efficacy and biological relevance offer an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents. 

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4. “Bottled” spiro-doubly aromatic trinuclear [Pd ₂ Ru] ⁺ complexes

   https://doi.org/10.1039/D0SC04469E  

   Kulichenko, Maksim; Fedik, Nikita; Monfredini, Anna; Muñoz-Castro, Alvaro; Balestri, Davide; Boldyrev, Alexander I.; Maestri, Giovanni (January 2021, Chemical Science)

   null (Ed.)

   Following an ongoing interest in the study of transition metal complexes with exotic bonding networks, we report herein the synthesis of a family of heterobimetallic triangular clusters involving Ru and Pd atoms. These are the first examples of trinuclear complexes combining these nuclei. Structural and bonding analyses revealed both analogies and unexpected differences for these [Pd 2 Ru] + complexes compared to their parent [Pd 3 ] + peers. Noticeably, participation of the Ru atom in the π-aromaticity of the coordinated benzene ring makes the synthesized compound the second reported example of ‘bottled’ double aromaticity. This can also be referred to as spiroaromaticity due to the participation of Ru in two aromatic systems at a time. Moreover, the [Pd 2 Ru] + kernel exhibits unprecedented orbital overlap of Ru d z2 AO and two Pd d xy or d x2−y2 AOs. The present findings reveal the possibility of synthesizing stable clusters with delocalized metal–metal bonding from the combination of non-adjacent elements of the periodic table which has not been reported previously. 

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5. Chlorin spiro-Tröger's base as a prospective photosensitizer for photodynamic therapy of cancer.

   https://doi.org/10.1016/j.jphotochem.2024.115618  

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