skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: End-to-End Sequential Sampling and Reconstruction for MR Imaging
Accelerated MRI shortens acquisition time by subsampling in the measurement k-space. Recovering a high-fidelity anatomical image from subsampled measurements requires close cooperation between two components: (1) a sampler that chooses the subsampling pattern and (2) a reconstructor that recovers images from incomplete measurements. In this paper, we leverage the sequential nature of MRI measurements, and propose a fully differentiable framework that jointly learns a sequential sampling policy simultaneously with a reconstruction strategy. This co-designed framework is able to adapt during acquisition in order to capture the most informative measurements for a particular target (see the figure above). Experimental results on the fastMRI knee dataset demonstrate that the proposed approach successfully utilizes intermediate information during the sampling process to boost reconstruction performance. In particular, our proposed method outperforms the current state-of-the-art learned k-space sampling baseline on over 96% of test samples. We also investigate the individual and collective benefits of the sequential sampling and co-design strategies.  more » « less
Award ID(s):
2048237
PAR ID:
10320784
Author(s) / Creator(s):
; ; ; ; ;
Date Published:
Journal Name:
Proceedings of the Machine Learning for Health Conference
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. This work presents a platform that integrates a customized MRI data acquisition scheme with reconstruction and three-dimensional (3D) visualization modules along with a module for controlling an MRI-compatible robotic device to facilitate the performance of robot-assisted, MRI-guided interventional procedures. Using dynamically-acquired MRI data, the computational framework of the platform generates and updates a 3D model representing the area of the procedure (AoP). To image structures of interest in the AoP that do not reside inside the same or parallel slices, the MRI acquisition scheme was modified to collect a multi-slice set of intraoblique to each other slices; which are termed composing slices. Moreover, this approach interleaves the collection of the composing slices so the same k-space segments of all slices are collected during similar time instances. This time matching of the k-space segments results in spatial matching of the imaged objects in the individual composing slices. The composing slices were used to generate and update the 3D model of the AoP. The MRI acquisition scheme was evaluated with computer simulations and experimental studies. Computer simulations demonstrated that k-space segmentation and time-matched interleaved acquisition of these segments provide spatial matching of the structures imaged with composing slices. Experimental studies used the platform to image the maneuvering of an MRI-compatible manipulator that carried tubing filled with MRI contrast agent. In vivo experimental studies to image the abdomen and contrast enhanced heart on free-breathing subjects without cardiac triggering demonstrated spatial matching of imaged anatomies in the composing planes. The described interventional MRI framework could assist in performing real-time MRI-guided interventions. 
    more » « less
  2. Quantitative susceptibility mapping (QSM) involves acquisition and reconstruction of a series of images at multi-echo time points to estimate tissue field, which prolongs scan time and requires specific reconstruction technique. In this paper, we present our new framework, called Learned Acquisition and Reconstruction Op- timization (LARO), which aims to accelerate the multi-echo gradient echo (mGRE) pulse sequence for QSM. Our approach involves optimizing a Cartesian multi-echo k-space sampling pattern with a deep reconstruc- tion network. Next, this optimized sampling pattern was implemented in an mGRE sequence using Cartesian fan-beam k-space segmenting and ordering for prospective scans. Furthermore, we propose to insert a recur- rent temporal feature fusion module into the reconstruction network to capture signal redundancies along echo time. Our ablation studies show that both the optimized sampling pattern and proposed reconstruction strategy help improve the quality of the multi-echo image reconstructions. Generalization experiments show that LARO is robust on the test data with new pathologies and different sequence parameters. Our code is available at https://github.com/Jinwei1209/LARO-QSM.git . 
    more » « less
  3. Image reconstruction is the process of recovering an image from raw, under-sampled signal measurements, and is a critical step in diagnostic medical imaging, such as magnetic resonance imaging (MRI). Recently, data-driven methods have led to improved image quality in MRI reconstruction using a limited number of measurements, but these methods typically rely on the existence of a large, centralized database of fully sampled scans for training. In this work, we investigate federated learning for MRI reconstruction using end-to-end unrolled deep learning models as a means of training global models across multiple clients (data sites), while keeping individual scans local. We empirically identify a low-data regime across a large number of heterogeneous scans, where a small number of training samples per client are available and non-collaborative models lead to performance drops. In this regime, we investigate the performance of adaptive federated optimization algorithms as a function of client data distribution and communication budget. Experimental results show that adaptive optimization algorithms are well suited for the federated learning of unrolled models, even in a limited-data regime (50 slices per data site), and that client-sided personalization can improve reconstruction quality for clients that did not participate in training. 
    more » « less
  4. We introduce chroma subsampling for 3D point cloud attribute compression by proposing a novel technique to sample points irregularly placed in 3D space. While most current video compression standards use chroma subsampling, these chroma subsampling methods cannot be directly applied to 3D point clouds, given their irregularity and sparsity. In this work, we develop a framework to incorporate chroma subsampling into geometry-based point cloud encoders, such as region adaptive hierarchical transform (RAHT) and region adaptive graph Fourier transform (RAGFT). We propose different sampling patterns on a regular 3D grid to sample the points at different rates. We use a simple graph-based nearest neighbor interpolation technique to reconstruct the full resolution point cloud at the decoder end. Experimental results demonstrate that our proposed method provides significant coding gains with negligible impact on the reconstruction quality. For some sequences, we observe a bitrate reduction of 10-15% under the Bjontegaard metric. More generally, perceptual masking makes it possible to achieve larger bitrate reductions without visible changes in quality. 
    more » « less
  5. PurposeTo develop an improved k‐space reconstruction method using scan‐specific deep learning that is trained on autocalibration signal (ACS) data. TheoryRobust artificial‐neural‐networks for k‐space interpolation (RAKI) reconstruction trains convolutional neural networks on ACS data. This enables nonlinear estimation of missing k‐space lines from acquired k‐space data with improved noise resilience, as opposed to conventional linear k‐space interpolation‐based methods, such as GRAPPA, which are based on linear convolutional kernels. MethodsThe training algorithm is implemented using a mean square error loss function over the target points in the ACS region, using a gradient descent algorithm. The neural network contains 3 layers of convolutional operators, with 2 of these including nonlinear activation functions. The noise performance and reconstruction quality of the RAKI method was compared with GRAPPA in phantom, as well as in neurological and cardiac in vivo data sets. ResultsPhantom imaging shows that the proposed RAKI method outperforms GRAPPA at high (≥4) acceleration rates, both visually and quantitatively. Quantitative cardiac imaging shows improved noise resilience at high acceleration rates (rate 4:23% and rate 5:48%) over GRAPPA. The same trend of improved noise resilience is also observed in high‐resolution brain imaging at high acceleration rates. ConclusionThe RAKI method offers a training database‐free deep learning approach for MRI reconstruction, with the potential to improve many existing reconstruction approaches, and is compatible with conventional data acquisition protocols. 
    more » « less