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Title: A multi-scale cholera model linking between-host and within-host dynamics
We propose a multi-scale modeling framework to investigate the transmission dynamics of cholera. At the population level, we employ a SIR model for the between-host transmission of the disease. At the individual host level, we describe the evolution of the pathogen within the human body. The between-host and within-host dynamics are connected through an environmental equation that characterizes the growth of the pathogen and its interaction with the hosts outside the human body. We put a special emphasis on the within-host dynamics by making a distinction for each individual host. We conduct both mathematical analysis and numerical simulation for our model in order to explore various scenarios associated with cholera transmission and to better understand the complex, multi-scale disease dynamics.  more » « less
Award ID(s):
1720222
PAR ID:
10323052
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
International Journal of Biomathematics
Volume:
11
Issue:
03
ISSN:
1793-5245
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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