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Title: Construction of vicinal 4°/3°-carbons via reductive Cope rearrangement
Herein reported is a strategy for constructing vicinal 4°/3° carbons via reductive Cope rearrangement. Substrates have been designed which exhibit Cope rearrangement kinetic barriers of ∼23 kcal mol −1 with isoenergetic favorability (Δ G ∼ 0). These fluxional/shape-shifting molecules can be driven forward by chemoselective reduction to useful polyfunctionalized building blocks.
Authors:
; ; ; ; ;
Award ID(s):
1844443
Publication Date:
NSF-PAR ID:
10323713
Journal Name:
Chemical Science
Volume:
13
Issue:
7
Page Range or eLocation-ID:
1951 to 1956
ISSN:
2041-6520
Sponsoring Org:
National Science Foundation
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