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Title: Construction of vicinal 4°/3°-carbons via reductive Cope rearrangement
Herein reported is a strategy for constructing vicinal 4°/3° carbons via reductive Cope rearrangement. Substrates have been designed which exhibit Cope rearrangement kinetic barriers of ∼23 kcal mol −1 with isoenergetic favorability (Δ G ∼ 0). These fluxional/shape-shifting molecules can be driven forward by chemoselective reduction to useful polyfunctionalized building blocks.
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Journal Name:
Chemical Science
Page Range or eLocation-ID:
1951 to 1956
Sponsoring Org:
National Science Foundation
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