More Like this

1. Task-Optimized Retinal-Inspired CNN Converges to Biologically-Plausible Functionality

   Murray, K.; Wang, B.; Lynch, N. (January 2021, 8th Workshop on Biological Distributed Algorithms (BDA))

   Convolutional neural networks (CNN) are an emerging technique in modeling neural circuits and have been shown to converge to biologically plausible functionality in cortical circuits via task-optimization. This functionality has not been observed in CNN models of retinal circuits via task-optimization. We sought to observe this convergence in retinal circuits by designing a biologically inspired CNN model of a motion-detection retinal circuit and optimizing it to solve a motion-classification task. The learned weights and parameters indicated that the CNN converged to direction-sensitive ganglion and amacrine cells, cell types that have been observed in biology, and provided evidence that task-optimization is a fair method of building retinal models. The analysis used to understand the functionality of our CNN also indicates that biologically constrained deep learning models are easier to reason about their underlying mechanisms than traditional deep learning models. 

   more » « less
2. Emergence of direction-selective retinal cell types in task-optimized deep learning models

   Murray, K.; Wang, B.; Lynch, N. (January 2022, Journal of computational biology)

   Convolutional neural networks (CNNs), a class of deep learning models, have experienced recent success in modeling sensory cortices and retinal circuits through optimizing performance on machine learning tasks, otherwise known as task optimization. Previous research has shown task-optimized CNNs to be capable of providing explanations as to why the retina efficiently encodes natural stimuli and how certain retinal cell types are involved in efficient encoding. In our work, we sought to use task-optimized CNNs as a means of explaining computational mechanisms responsible for motion-selective retinal circuits. We designed a biologically constrained CNN and optimized its performance on a motion-classification task. We drew inspiration from psychophysics, deep learning, and systems neuroscience literature to develop a toolbox of methods to reverse engineer the computational mechanisms learned in our model. Through reverse engineering our model, we proposed a computational mechanism in which direction-selective ganglion cells and starburst amacrine cells, both experimentally observed retinal cell types, emerge in our model to discriminate among moving stimuli. This emergence suggests that direction-selective circuits in the retina are ecologically designed to robustly discriminate among moving stimuli. Our results and methods also provide a framework for how to build more interpretable deep learning models and how to understand them. 

   more » « less
3. Transferable Two-Stream Convolutional Neural Network for Human Action Recognition

   Xiong, Q. (January 2020, 48th North American Manufacturing Research Conference)

   Human-Robot Collaboration (HRC), which envisions a workspace in which human and robot can dynamically collaborate, has been identified as a key element in smart manufacturing. Human action recognition plays a key role in the realization of HRC as it helps identify current human action and provides the basis for future action prediction and robot planning. Despite recent development of Deep Learning (DL) that has demonstrated great potential in advancing human action recognition, one of the key issues remains as how to effectively leverage the temporal information of human motion to improve the performance of action recognition. Furthermore, large volume of training data is often difficult to obtain due to manufacturing constraints, which poses challenge for the optimization of DL models. This paper presents an integrated method based on optical flow and convolutional neural network (CNN)-based transfer learning to tackle these two issues. First, optical flow images, which encode the temporal information of human motion, are extracted and serve as the input to a two-stream CNN structure for simultaneous parsing of spatial-temporal information of human motion. Then, transfer learning is investigated to transfer the feature extraction capability of a pretrained CNN to manufacturing scenarios. Evaluation using engine block assembly confirmed the effectiveness of the developed method. 

   more » « less
4. Formalizing locality for normative synaptic plasticity models

   Bredenberg, E; Williams, E; Savin, C; Richards, B; Lajoie, G (September 2023, Advances In Neural Information Processing Systems (NeurIPS))

   In recent years, many researchers have proposed new models for synaptic plasticity in the brain based on principles of machine learning. The central motivation has been the development of learning algorithms that are able to learn difficult tasks while qualifying as "biologically plausible". However, the concept of a biologically plausible learning algorithm is only heuristically defined as an algorithm that is potentially implementable by biological neural networks. Further, claims that neural circuits could implement any given algorithm typically rest on an amorphous concept of "locality" (both in space and time). As a result, it is unclear what many proposed local learning algorithms actually predict biologically, and which of these are consequently good candidates for experimental investigation. Here, we address this lack of clarity by proposing formal and operational definitions of locality. Specifically, we define different classes of locality, each of which makes clear what quantities cannot be included in a learning rule if an algorithm is to qualify as local with respect to a given (biological) constraint. We subsequently use this framework to distill testable predictions from various classes of biologically plausible synaptic plasticity models that are robust to arbitrary choices about neural network architecture. Therefore, our framework can be used to guide claims of biological plausibility and to identify potential means of experimentally falsifying a proposed learning algorithm for the brain. 

   more » « less
5. Reinforcement Learning for Central Pattern Generation in Dynamical Recurrent Neural Networks

   https://doi.org/10.3389/fncom.2022.818985  

   Yoder, Jason A.; Anderson, Cooper B.; Wang, Cehong; Izquierdo, Eduardo J. (April 2022, Frontiers in Computational Neuroscience)

   Lifetime learning, or the change (or acquisition) of behaviors during a lifetime, based on experience, is a hallmark of living organisms. Multiple mechanisms may be involved, but biological neural circuits have repeatedly demonstrated a vital role in the learning process. These neural circuits are recurrent, dynamic, and non-linear and models of neural circuits employed in neuroscience and neuroethology tend to involve, accordingly, continuous-time, non-linear, and recurrently interconnected components. Currently, the main approach for finding configurations of dynamical recurrent neural networks that demonstrate behaviors of interest is using stochastic search techniques, such as evolutionary algorithms. In an evolutionary algorithm, these dynamic recurrent neural networks are evolved to perform the behavior over multiple generations, through selection, inheritance, and mutation, across a population of solutions. Although, these systems can be evolved to exhibit lifetime learning behavior, there are no explicit rules built into these dynamic recurrent neural networks that facilitate learning during their lifetime (e.g., reward signals). In this work, we examine a biologically plausible lifetime learning mechanism for dynamical recurrent neural networks. We focus on a recently proposed reinforcement learning mechanism inspired by neuromodulatory reward signals and ongoing fluctuations in synaptic strengths. Specifically, we extend one of the best-studied and most-commonly used dynamic recurrent neural networks to incorporate the reinforcement learning mechanism. First, we demonstrate that this extended dynamical system (model and learning mechanism) can autonomously learn to perform a central pattern generation task. Second, we compare the robustness and efficiency of the reinforcement learning rules in relation to two baseline models, a random walk and a hill-climbing walk through parameter space. Third, we systematically study the effect of the different meta-parameters of the learning mechanism on the behavioral learning performance. Finally, we report on preliminary results exploring the generality and scalability of this learning mechanism for dynamical neural networks as well as directions for future work. 

   more » « less