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Long-term and high-dose prescription opioid use places individuals at risk for opioid misuse, opioid use disorder (OUD), and overdose. Existing methods for monitoring opioid use and detecting misuse rely on self-reports, which are prone to reporting bias, and toxicology testing, which may be infeasible in outpatient settings. Although wearable technologies for monitoring day-to-day health metrics have gained significant traction in recent years due to their ease of use, flexibility, and advancements in sensor technology, their application within the opioid use space remains underexplored. In the current work, we demonstrate that oral opioid administrations can be detected using physiological signals collected from a wrist sensor. More importantly, we show that models informed by opioid pharmacokinetics increase reliability in predicting the timing of opioid administrations. Forty-two individuals who were prescribed opioids as a part of their medical treatment in-hospital and after discharge were enrolled. Participants wore a wrist sensor throughout the study, while opioid administrations were tracked using electronic medical records and self-reports. We collected 1,983 hours of sensor data containing 187 opioid administrations from the inpatient setting and 927 hours of sensor data containing 40 opioid administrations from the outpatient setting. We demonstrate that a self-supervised pre-trained model, capable of learning the canonical time series of plasma concentration of the drug derived from opioid pharmacokinetics, can reliably detect opioid administration in both settings. Our work suggests the potential of pharmacokinetic-informed, data-driven models to objectively detect opioid use in daily life.
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Boosting Lying Posture Classification with Transfer Learning
Automatic lying posture tracking is an important factor in human health monitoring. The increasing popularity of the wrist-based trackers provides the means for unobtrusive, affordable, and long-term monitoring with minimized privacy concerns for the end-users and promising results in detecting the type of physical activity, step counting, and sleep quality assessment. However, there is limited research on development of accurate and efficient lying posture tracking models using wrist-based sensor. Our experiments demonstrate a major drop in the accuracy of the lying posture tracking using wrist-based accelerometer sensor due to the unpredictable noise from arbitrary wrist movements and rotations while sleeping. In this paper, we develop a deep transfer learning method that improves performance of lying posture tracking using noisy data from wrist sensor by transferring the knowledge from an initial setting which contains both clean and noisy data. The proposed solution develops an optimal mapping model from the noisy data to the clean data in the initial setting using LSTM sequence regression, and reconstruct clean synthesized data in another setting where no noisy sensor data is available. This increases the lying posture tracking F1-Score by 24.9% for left-wrist and by 18.1% for right-wrist sensors comparing to the case without mapping.
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- Award ID(s):
- 2210133
- PAR ID:
- 10325314
- Date Published:
- Journal Name:
- The 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2022)
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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