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Inter-beat interval (IBI) measurement enables estimation of heart-tare variability (HRV) which, in turn, can provide early indication of potential cardiovascular diseases (CVDs). However, extracting IBIs from noisy signals is challenging since the morphology of the signal gets distorted in the presence of noise. Electrocardiogram (ECG) of a person in heavy motion is highly corrupted with noise, known as motion-artifact, and IBI extracted from it is inaccurate. As a part of remote health monitoring and wearable system development, denoising ECG signals and estimating IBIs correctly from them have become an emerging topic among signal-processing researchers. Apart from conventional methods, deep-learning techniques have been successfully used in signal denoising recently, and diagnosis process has become easier, leading to accuracy levels that were previously unachievable. We propose a deep-learning approach leveraging tiramisu autoencoder model to suppress motion-artifact noise and make the R-peaks of the ECG signal prominent even in the presence of high-intensity motion. After denoising, IBIs are estimated more accurately expediting diagnosis tasks. Results illustrate that our method enables IBI estimation from noisy ECG signals with SNR up to -30 dB with average root mean square error (RMSE) of 13 milliseconds for estimated IBIs. At this noise level, our error percentage remains below 8% and outperforms other state-of-the-art techniques. 

Activity recognition using data collected with smart devices such as mobile and wearable sensors has become a critical component of many emerging applications ranging from behavioral medicine to gaming. However, an unprecedented increase in the diversity of smart devices in the internet-of-things era has limited the adoption of activity recognition models for use across different devices. This lack of cross-domain adaptation is particularly notable across sensors of different modalities where the mapping of the sensor data in the traditional feature level is highly challenging. To address this challenge, we propose ActiLabel, a combinatorial framework that learns structural similarities among the events that occur in a target domain and those of a source domain and identifies an optimal mapping between the two domains at their structural level. The structural similarities are captured through a graph model, referred to as the dependency graph, which abstracts details of activity patterns in low-level signal and feature space. The activity labels are then autonomously learned in the target domain by finding an optimal tiered mapping between the dependency graphs. We carry out an extensive set of experiments on three large datasets collected with wearable sensors involving human subjects. The results demonstrate the superiority of ActiLabel over state-of-the-art transfer learning and deep learning methods. In particular, ActiLabel outperforms such algorithms by average F1-scores of 36.3%, 32.7%, and 9.1% for cross-modality, cross-location, and cross-subject activity recognition, respectively. 

Physical activity is a cornerstone of chronic conditions and one of the most critical factors in reducing the risks of cardiovascular diseases, the leading cause of death in the United States. App-based lifestyle interventions have been utilized to promote physical activity in people with or at risk for chronic conditions. However, these mHealth tools have remained largely static and do not adapt to the changing behavior of the user. In a step toward designing adaptive interventions, we propose BeWell24Plus, a framework for monitoring activity and user engagement and developing computational models for outcome prediction and intervention design. In particular, we focus on devising algorithms that combine data about physical activity and engagement with the app to predict future physical activity performance. Knowing in advance how active a person is going to be in the next day can help with designing adaptive interventions that help individuals achieve their physical activity goals. Our technique combines the recent history of a person's physical activity with app engagement metrics such as when, how often, and for how long the app was used to forecast the near future's activity. We formulate the problem of multimodal activity forecasting and propose an LSTM-based realization of our proposed model architecture, which estimates physical activity outcomes in advance by examining the history of app usage and physical activity of the user. We demonstrate the effectiveness of our forecasting approach using data collected with 58 prediabetic people in a 9-month user study. We show that our multimodal forecasting approach outperforms single-modality forecasting by 2.2$ to 11.1% in mean-absolute-error. 

Postprandial hyperglycemia (PPHG) is detrimental to health and increases risk of cardiovascular diseases, reduced eyesight, and life-threatening conditions like cancer. Detecting PPHG events before they occur can potentially help with providing early interventions. Prior research suggests that PPHG events can be predicted based on information about diet. However, such computational approaches (1) are data hungry requiring significant amounts of data for algorithm training; and (2) work as a black-box and lack interpretability, thus limiting the adoption of these technologies for use in clinical interventions. Motivated by these shortcomings, we propose, DietNudge 1 , a machine learning based framework that integrates multi-modal data about diet, insulin, and blood glucose to predict PPHG events before they occur. Using data from patients with diabetes, we demonstrate that our model can predict PPHG events with up to 90% classification accuracy and an average F1 score of 0.93. The proposed decision-tree-based approach also identifies modifiable factors that contribute to an impending PPHG event while providing personalized thresholds to prevent such events. Our results suggest that we can develop simple, yet effective, computational algorithms that can be used as preventative mechanisms for diabetes and obesity management. 

Stress detection and monitoring is an active area of research with important implications for an individual's personal, professional, and social health. Current approaches for stress classification use traditional machine learning algorithms trained on features computed from multiple sensor modalities. These methods are data and computation-intensive, rely on hand-crafted features, and lack reproducibility. These limitations impede the practical use of stress detection and classification systems in the real world. To overcome these shortcomings, we propose Stressalyzer, a novel stress classification and personalization framework from single-modality sensor data without feature computation and selection. Stressalyzer uses only Electrodermal activity (EDA) sensor data while providing competitive results compared to the state-of-the-art techniques that use multiple sensor modalities and are computationally expensive due to the calculation of large number of features. Using the dataset collected in a laboratory setting from $15$ subjects, our single-channel neural network-based model achieves a classification accuracy of 92.9% and an f1 score of 0.89 for binary stress classification. Our leave-one-subject-out analysis establishes the subjective nature of stress and shows that personalizing stress models using Stressalyzer significantly improves the model performance. Without model personalization, we found a performance decline in 40% of the subjects, suggesting the need for model personalization. 

The recent success of deep neural networks in prediction tasks on wearable sensor data is evident. However, in more practical online learning scenarios, where new data arrive sequentially, neural networks suffer severely from the ``catastrophic forgetting`` problem. In real-world settings, given a pre-trained model on the old data, when we collect new data, it is practically infeasible to re-train the model on both old and new data because the computational costs will increase dramatically as more and more data arrive in time. However, if we fine-tune the model only with the new data because the new data might be different from the old data, the neural network parameters will change to fit the new data. As a result, the new parameters are no longer suitable for the old data. This phenomenon is known as catastrophic forgetting, and continual learning research aims to overcome this problem with minimal computational costs. While most of the continual learning research focuses on computer vision tasks, implications of catastrophic forgetting in wearable computing research and potential avenues to address this problem have remained unexplored. To address this knowledge gap, we study continual learning for activity recognition using wearable sensor data. We show that the catastrophic forgetting problem is a critical challenge for real-world deployment of machine learning models for wearables. Moreover, we show that the catastrophic forgetting problem can be alleviated by employing various training techniques.