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Title: A new pseudopolymorph of berberine chloride: crystal structure and Hirshfeld surface analysis
A new pseudopolymorph of berberine, 9,10-dimethoxy-5,6-dihydro-2 H -7λ 5 -[1,3]dioxolo[4,5- g ]isoquinolino[3,2- a ]isoquinolin-7-ylium chloride methanol monosolvate, C 20 H 18 NO 4 + ·Cl − ·CH 3 OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetrahydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the intermolecular interactions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.  more » « less
Award ID(s):
2122108
PAR ID:
10329139
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Acta Crystallographica Section E Crystallographic Communications
Volume:
78
Issue:
5
ISSN:
2056-9890
Page Range / eLocation ID:
468 to 472
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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