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1. Skin Deep

   https://doi.org/10.70312/QVNS  

   Nading, Alex (June 2025, Limn)

   What if skin care is really planetary care? 

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2. Tilapia Fish Skin Treatment of Third-Degree Skin Burns in Murine Model

   https://doi.org/10.3390/jfb14100512  

   Garrity, Carissa; Garcia-Rovetta, Christina; Rivas, Iris; Delatorre, Ubaldo; Wong, Alice; Kültz, Dietmar; Peyton, Jamie; Arzi, Boaz; Vapniarsky, Natalia (October 2023, Journal of Functional Biomaterials)

   This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Despite the promises of this therapy, there are few studies explaining the healing mechanisms behind the application of tilapia fish skin. In this study, mice with third-degree burns were treated with either a hydrocolloid adhesive bandage (control) (n = 16) or fish skin (n = 16) 7 days post-burn. Mice were subjected to histologic, hematologic, molecular, and gross evaluation at days 7, 16, and 28 post-burn. The fish skin offered no benefit to overall wound closure compared to hydrocolloids. Additionally, we detected no difference between fish skin and control treatments in regard to hypermetabolism or hematologic values. However, the fish skin groups exhibited 2 times more vascularization and 2 times higher expression of antimicrobial defensin peptide in comparison to controls. Proteomic analysis of the fish skin revealed the presence of antimicrobial peptides. Collectively, these data suggest that fish skin can serve as an innovative and cost-effective therapeutic alternative for burn victims to facilitate vascularization and reduce bacterial infection. 

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3. Effect of burn wound treatment with fish skin on mouse skin proteome

   https://doi.org/10.6069/332v-vt13  

   Vapniarsky, Natalia; Kültz, Dietmar (January 2024, Panorama Public)

   This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Proteomic analysis of the fish skin revealed the presence of antimicrobial peptides. In combination with histological and other data, these results suggest that fish skin can serve as an innovative and cost-effective therapeutic alternative for burn victims to facilitate vascularization and reduce bacterial infection. 

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4. Vitrification and ultra-rapid warming of mouse skin

   https://doi.org/10.1016/j.cryobiol.2023.104667  

   Namsrai, Bat-Erdene; Han, Zonghu; Etheridge, Michael; Bischof, John; Finger, Erik (December 2023, Cryobiology)
5. Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

   https://doi.org/10.1126/sciadv.abd7703  

   Wei, Lei; Christensen, Sean R.; Fitzgerald, Megan E.; Graham, James; Hutson, Nicholas D.; Zhang, Chi; Huang, Ziyun; Hu, Qiang; Zhan, Fenglin; Xie, Jun; et al (January 2021, Science Advances)

   null (Ed.)

   In ultraviolet (UV) radiation–exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples. The number and relative contribution of CMs were significantly different between SE and NE areas. Furthermore, we identified hotspots in TP53 , NOTCH1 , and GRM3 where mutations were significantly associated with UV exposure. In the normal skin from patients with cutaneous squamous cell carcinoma, we found that the cancer burden was associated with the UV-induced mutations, with the difference mostly conferred by the low-frequency CMs. These findings provide previously unknown information on UV’s carcinogenic effect and pave the road for future development of quantitative assessment of subclinical UV damage and skin cancer risk. 

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