A two-dimensional array of microfluidic ports with remote-controlled valve actuation is of great interest for applications involving localized chemical stimulation. Herein, a macroporous silicon-based platform where each pore contains an independently controllable valve made from poly(N-isopropylacrylamide) (PNIPAM) brushes is proposed. These valves are coated with silica-encapsulated gold nanorods (GNRs) for NIR-actuated switching capability. The layer-by-layer (LBL) electrostatic deposition technique was used to attach the GNRs to the PNIPAM brushes. The deposition of GNRs was confirmed by dark-field optical microscopy, and the localized surface plasmon resonance (LSPR) of the deposited GNRs was analyzed using UV-Vis spectra. To evaluate the chemical release behaviors, fluorescein dye was employed as a model substance. The chemical release properties, like OFF-state diffusion through the valve, the ratio between ON-state and OFF-state chemical release, and the rapidness of chemical modulation of the valve, were investigated, varying the PNIPAM brush thickness. The results indicate that enhancing the thickness of the PNIPAM brush in our platform improves control over the chemical modulation properties. However, excessive increases in brush length may lead to entanglement, which negatively impacts the chemical modulation efficiency.
more »
« less
Photothermal liquid release from arrayed Au nanorod/hydrogel composites for chemical stimulation
Abstract Controlled photothermal actuation of liquid release is presented using periodically arrayed hydrogel columns in a macroporous silicon membrane. Thermo-responsive hydrogel is mixed with Gold (Au) nanorods, and surface plasmon-induced local heating by near-infrared (NIR) light is utilized as an actuation method. We adopted theoretical modeling, which treats the hydrogel as a poro-viscoelastic medium to understand the mechanical and liquid transport properties of the hydrogel. To demonstrate the feasibility of the liquid release control using NIR light, we first characterized the temperature response of Au nanorod embedded hydrogel in the silicon membrane using its optical transmission behavior to confirm the successful device fabrication. Next, the liquid release characteristics from the structure were studied using fluorescent imaging of fluorescein dye solution while pulsed NIR light was illuminated on the structure. We successfully demonstrate that the liquid release can be controlled using remote NIR illumination from the presented structure. Considering the periodically arrayed configuration with high spatial resolution, this will have a potential prospect for optically-addressable chemical release systems, which benefit retina prosthesis interfaces.
more »
« less
- Award ID(s):
- 1952469
- PAR ID:
- 10330032
- Date Published:
- Journal Name:
- Journal of Micromechanics and Microengineering
- Volume:
- 32
- Issue:
- 1
- ISSN:
- 0960-1317
- Page Range / eLocation ID:
- 015003
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Controlled-release materials are desirable for many delivery applications and have been used to improve the efficiency of fertilizers and pesticides in crop management. Due to their potential to reduce application of toxic chemicals while prolonging exposure to active agents, controlled-release nanomaterials are currently being investigated for increasing agricultural production and preventing overfertilization. Hydrogels are underexplored as controlled-release nanomaterials and can deliver many types of cargo, from metal ions to small molecules. Alginate-based hydrogels are biocompatible and their internal carboxylic acids coordinate agriculturally valuable micronutrients like Cu2+, Zn2+, and Ca2+. Hydrogels comprising ionic and nonionic polymers can coordinate agriculturally valuable micronutrients, and the combination of ionic and nonionic polymers results in hydrogels with tunable release profiles. Alginate, for example, contains carboxylates that ionically cross-link with divalent cations like Cu2+, Zn2+, and Ca2+, while polar moieties on chitin enable nonionic coordination. To our knowledge, soft-material copper-loaded nanoparticles have not yet been applied as controlled-release materials for foliar delivery. In this work, we present the synthesis and micronutrient release characteristics of hydrogel nanoparticles containing Cu2+, which is coordinated by ionic and nonionic polymers. Hydrogel nanoparticles (HNPs) were prepared by liquid–liquid emulsion techniques and cross-linked with Cu2+ to form double-network hydrogels made from alginate and non-cross-linking chitin. Nanoparticles (100–300 nm in diameter) were characterized by cryogenic electron microscopy, nanoparticle tracking analysis, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The copper release profiles of HNPs with different polymer compositions were compared. HNPs containing both chitin and alginate released 8–20 times more copper than HNPs with alginate alone, suggesting that the presence of non-cross-linking polymers improves copper release. Thus, HNP delivery characteristics can be tuned by manipulating intraparticle bond dynamics in the hydrogel polymer matrix.more » « less
-
A new lens capability for three-dimensional (3D) focal control is presented using an optofluidic system consisting ofn × narrayed liquid prisms. Each prism module contains two immiscible liquids in a rectangular cuvette. Using the electrowetting effect, the shape of the fluidic interface can be rapidly adjusted to create its straight profile with the prism’s apex angle. Consequently, an incoming ray is steered at the tilted interface due to the refractive index difference between two liquids. To achieve 3D focal control, individual prisms in the arrayed system are simultaneously modulated, allowing incoming light rays to be spatially manipulated and converged on a focal point located atPfocal(fx,fy,fz) in 3D space. Analytical studies were conducted to precisely predict the prism operation required for 3D focal control. Using three liquid prisms positioned on thex-,y-, and 45°-diagonal axes, we experimentally demonstrated 3D focal tunability of the arrayed optofluidic system, achieving focal tuning along lateral, longitudinal, and axial directions as wide as 0 ≤ fx ≤ 30 mm, 0 ≤ fy ≤ 30 mm, and 500 mm ≤ fz ≤ ∞. This focal tunability of the arrayed system allows for 3D control of the lens’s focusing power, which could not be attained by solid-type optics without the use of bulky and complex mechanical moving components. This innovative lens capability for 3D focal control has potential applications in eye-movement tracking for smart displays, autofocusing of smartphone cameras, or solar tracking for smart photovoltaic systems.more » « less
-
Abstract Controllable and long‐term release remains a great challenge in current drug delivery systems. Benefiting from their efficient drug loading and painless administration, microneedles (MNs) have emerged as a promising platform for transdermal drug delivery, while they often fail to achieve long‐term tissue adhesion and controllable extended drug release. Here, 3D printing of an innovative MN patch is presented with succulent‐inspired responsive microstructures and light‐controllable long‐term release capability. The MN exhibits a reversible shrink‐swell volume change behavior in response to surrounding humidity, which enables sufficient mechanical strength for skin penetration under the shrinkage conditions and efficient long‐term adhesion when swollen in skin tissues. Moreover, the MN patch introduces a controllable long‐term drug release system, achieved through the integration of thiolated heparin (Hep‐SH) for sustained growth factor release and graphene oxide (GO) nanosheets for controlled drug release via near infrared (NIR) laser irradiation. The MN patches with growth factor loading have good biocompatibility and can promote the proliferation, migration, and proangiogenesis of endothelial cells is further demonstrated. Thus, it is believed that such flexible MN patches can be promising candidates for controllable long‐term transdermal drug delivery as well as other related tissue engineering applications.more » « less
-
Two dimensional (2D) materials such as graphene and transition metal dichalcogenides (TMDs) are promising for optical modulation, detection, and light emission since their material properties can be tuned on-demand via electrostatic doping1–21. The optical properties of TMDs have been shown to change drastically with doping in the wavelength range near the excitonic resonances22–26. However, little is known about the effect of doping on the optical properties of TMDs away from these resonances, where the material is transparent and therefore could be leveraged in photonic circuits. Here, we probe the electro-optic response of monolayer TMDs at near infrared (NIR) wavelengths (i.e. deep in the transparency regime), by integrating them on silicon nitride (SiN) photonic structures to induce strong light -matter interaction with the monolayer. We dope the monolayer to carrier densities of (7.2 ± 0.8) × 1013 cm-2, by electrically gating the TMD using an ionic liquid [P14+] [FAP-]. We show strong electro-refractive response in monolayer tungsten disulphide (WS2) at NIR wavelengths by measuring a large change in the real part of refractive index ∆n = 0.53, with only a minimal change in the imaginary part ∆k = 0.004. We demonstrate photonic devices based on electrostatically gated SiN-WS2 phase modulator with high efficiency ( ) of 0.8 V · cm. We show that the induced phase change relative to the change in absorption (i.e. ∆n/∆k) is approximately 125, that is significantly higher than the ones achieved in 2D materials at different spectral ranges and in bulk materials, commonly employed for silicon photonic modulators such as Si and III-V on Si, while accompanied by negligible insertion loss. Efficient phase modulators are critical for enabling large-scale photonic systems for applications such as Light Detection and Ranging (LIDAR), phased arrays, optical switching, coherent optical communication and quantum and optical neural networks27–30.more » « less
An official website of the United States government

